程序性细胞死亡在小鼠眼视网膜发育过程中的作用。

Programmed cell death during retinal development of the mouse eye.

机构信息

Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.

出版信息

Adv Exp Med Biol. 2014;801:9-13. doi: 10.1007/978-1-4614-3209-8_2.

Abstract

Similar to other parts of the central nervous system, there are two types of programmed cell death during retinal development. In early development, the neuronal progenitor population is affected. In the mouse eye, this kind of programmed cell death begins at around embryonic day (E) 12.5 and peaks between E14.5 and E16.5. The second phase of programmed cell death occurs during synaptogenesis within the first 2 postnatal weeks. Important signaling mechanisms that induce programmed cell death of retinal progenitors appear to involve nerve growth factor acting on the proapoptotic receptor to p75 neurotrophin receptor (p75(NTR)) and transforming growth factor-β.

摘要

类似于中枢神经系统的其他部位，视网膜发育过程中有两种类型的程序性细胞死亡。在早期发育中，神经元祖细胞群体受到影响。在小鼠眼中，这种程序性细胞死亡始于胚胎第 12.5 天（E）左右，并在 E14.5 至 E16.5 之间达到高峰。第二个程序性细胞死亡阶段发生在出生后前 2 周内的突触发生过程中。诱导视网膜祖细胞程序性细胞死亡的重要信号机制似乎涉及神经生长因子作用于促凋亡受体 p75 神经营养因子受体（p75（NTR））和转化生长因子-β。