A double-blind crossover comparison of amlodipine and placebo added to captopril in moderate to severe hypertension.
作者信息
Maclean D, Mitchell E T, Wilcox R G, Walker P, Tyler H M
机构信息
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland.
出版信息
J Cardiovasc Pharmacol. 1988;12 Suppl 7:S85-8. doi: 10.1097/00005344-198812007-00019.
Abstract
Amlodipine 10 mg once daily added to captopril 25 mg twice daily for 4 weeks in patients with moderate to severe hypertension significantly improved blood pressure control (by -18/-12 and -20/-12 mm Hg for supine and standing systolic/diastolic pressures respectively, p less than 0.001). Few side effects related to amlodipine were noted and none was serious.
摘要
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