血管生成活性的鉴定以及血小板衍生内皮细胞生长因子的克隆与表达。
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
作者信息
Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W, Heldin C H
机构信息
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
出版信息
Nature. 1989 Apr 13;338(6216):557-62. doi: 10.1038/338557a0.
DOI:10.1038/338557a0
PMID:2467210
Abstract
Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.
摘要
血小板衍生内皮细胞生长因子互补DNA的克隆与测序表明，它是一种不同于以往所描述蛋白质的新型因子。该因子是一种相对分子质量约为45,000的蛋白质，在体外可刺激内皮细胞生长和趋化作用，在体内可促进血管生成。
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