Farah Chadi, Rouhayem Ziad, Nassif Charbel, Rassi Simon
J Med Liban. 2014 Jan-Mar;62(1):7-13.
To define the predictive factors of recurrence of the pediatric acquired cholesteatoma in order to improve the long-term results, to restore a good hearing function and to prevent the complications.
A retrospective study concerning all cases of pediatric acquired cholesteatoma, treated during the period 1997-2008 in our center, and followed up for at least one year. A description of the parameters concerning the patients, disease and treatment as well as a univariate analysis were undertaken in order to determine the recurrence predictors. The recurrence-free survival was calculated using the Kaplan-Meier method.
26 ears were studied and followed over a mean period of 62 months after the first intervention. The mean age was 12 years (11.7 years) with a 2.7 sex-ratio. The main clinical presentations were otorrhea (65%) and hypoacusia in 42% of cases. Fifteen cases (57.7%) presented an extension to the mastoid, 50% of the ears had an ossicular erosion and 11 cholesteatomas revealed a local or regional invasion. Almost 3/4 (73%) of the cholesteatomas were treated using a canal wall up surgery. The cumulative rate of recurrence was 53.8% and the rate of recurrence-free survival was 84%, 56%, and 44.7% at 12, 24 and 36 months respectively. Only the extension of the cholesteatoma to the mastoid, and the local and regional invasion (sinus tympani, lateral semi-circular canal, facial nerve recess, etc.) of the cholesteatoma at diagnosis, showed a significant higher risk of recurrence (p < 0.05).
In our study, the extent of the disease at diagnosis is considered as the major predictive factor of recurrence in pediatric acquired cholesteatoma population raising the problem of delayed diagnosis.
确定儿童获得性胆脂瘤复发的预测因素,以改善长期疗效,恢复良好的听力功能并预防并发症。
一项回顾性研究,涉及1997年至2008年期间在本中心接受治疗且随访至少一年的所有儿童获得性胆脂瘤病例。对有关患者、疾病和治疗的参数进行了描述,并进行了单因素分析以确定复发预测因素。采用Kaplan-Meier方法计算无复发生存率。
对26只耳朵进行了研究,首次干预后平均随访62个月。平均年龄为12岁(11.7岁),性别比为2.7。主要临床表现为耳漏(65%),42%的病例有听力减退。15例(57.7%)出现乳突扩展,50%的耳朵有听骨侵蚀,11例胆脂瘤显示局部或区域侵犯。几乎3/4(73%)的胆脂瘤采用开放式鼓室成形术治疗。累积复发率为53.8%,12、24和36个月时的无复发生存率分别为84%、56%和44.7%。仅胆脂瘤向乳突的扩展以及诊断时胆脂瘤的局部和区域侵犯(鼓室窦、外半规管、面神经隐窝等)显示出显著更高的复发风险(p<0.05)。
在我们的研究中,诊断时疾病的范围被认为是儿童获得性胆脂瘤人群复发的主要预测因素,这引发了诊断延迟的问题。