复制体复合物成分——翻译后修饰及其影响。

Replisome components--post-translational modifications and their effects.

机构信息

Warwick Medical School, University of Warwick, Gibbert Hill Campus, CV47AL Coventry, UK.

出版信息

Semin Cell Dev Biol. 2014 Jun;30:144-53. doi: 10.1016/j.semcdb.2014.03.026. Epub 2014 Mar 28.

DOI:10.1016/j.semcdb.2014.03.026

Abstract

The process of DNA replication is highly regulated, but at the same time very dynamic. Once S-phase is initiated and replication elongation is occurring, the cells are committed to complete replication in order to ensure genome stability and survival. Many pathways exist to resolve situations where normal replisome progression is not possible. It is becoming more and more evident that post-translational modifications of replisome components play a key role in regulating these pathways which ensure fork progression. Here we review the known modifications of the progressing replisome and how these modifications are thought to affect DNA replication in unperturbed and perturbed S-phases.

摘要

DNA 复制过程受到高度调控，但同时也非常动态。一旦 S 期开始并发生复制延伸，细胞就会致力于完成复制，以确保基因组的稳定性和生存。存在许多途径来解决正常复制体进展不可能的情况。越来越明显的是，复制体组件的翻译后修饰在调节这些途径中起着关键作用，这些途径确保了叉的进展。在这里，我们回顾了正在进行的复制体的已知修饰，以及这些修饰如何影响未受干扰和受干扰的 S 期的 DNA 复制。