噬菌体纳米纤维在3D打印骨支架中诱导血管化骨生成。
Phage nanofibers induce vascularized osteogenesis in 3D printed bone scaffolds.
作者信息
Wang Jianglin, Yang Mingying, Zhu Ye, Wang Lin, Tomsia Antoni P, Mao Chuanbin
机构信息
Department of Chemistry and Biochemistry, University of Oklahoma, Stephenson Life Sciences Research Center, Norman, OK 73019, USA.
Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Yuhangtang Road 866, Hangzhou, Zhejiang 310058, China.
出版信息
Adv Mater. 2014 Aug 6;26(29):4961-4966. doi: 10.1002/adma.201400154. Epub 2014 Apr 7.
Abstract
A virus-activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high-density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs.
摘要
为克服形成血管化骨组织的挑战，研发了一种病毒激活基质。它是通过用展示高密度RGD肽的噬菌体纳米纤维填充3D打印的生物陶瓷支架而生成的。在用间充质干细胞（MSC）接种并植入骨缺损后，噬菌体纳米纤维通过激活MSC的内皮化和成骨分化来诱导成骨和血管生成。
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