Modification of radioiodine incorporation into the fetuses and newborn rats by thyroid blocking agents.

Combination of thyroid blocking agents do not seem to be embryo- and fetotoxic when applied in reduced doses. These agents decrease significantly the radioiodine uptake by fetuses and sucklings. By extrapolation of these results to humans, based on the mass-unit efficient doses [13, 16, 23, 24], their combination can be recommended for the prophylaxis of radioiodine intoxication of fetuses and infants.