Schario Marianne, Lünnemann Lena, Stroux Andrea, Reisshauer Anett, Zuberbier Torsten, Blume-Peytavi Ulrike, Garcia Bartels Natalie
Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Skin Pharmacol Physiol. 2014;27(4):208. doi: 10.1159/000360546. Epub 2014 Apr 3.
Dry skin reflects a skin barrier defect which can lead to atopic dermatitis. Little is known about the distinct effects of emollient use in children with dry skin and atopic predisposition.
We investigated the effects of daily application of pressed ice plant juice (PIPJ)-based emollients and petrolatum-based emollients.
Children aged 2-6 years with dry skin and atopic predisposition were randomized into 2 groups: group 1 received emollients containing PIPJ and natural lipids, while group 2 received petrolatum-based emollients. Skin condition and biophysical properties of the skin barrier were assessed at inclusion and weeks 4, 12 and 16.
Skin condition improved significantly in all children. Comparing the groups, children treated with emollients containing PIPJ showed significantly higher stratum corneum hydration values and significantly lower transepidermal water loss values at week 16 on the forearm and forehead. A significant decrease in skin pH was noted in group 2 on the forearm and forehead; group 1 showed a stable course.
Early intervention with emollients in children with dry skin condition and atopic predisposition may improve their skin condition during daily emollient application. PIPJ-based formulations may be helpful to maintain skin barrier integrity.
干性皮肤反映了一种皮肤屏障缺陷，可导致特应性皮炎。对于干性皮肤且有特应性倾向的儿童使用润肤剂的不同效果知之甚少。
我们研究了每日涂抹基于冰叶日中花汁（PIPJ）的润肤剂和基于凡士林的润肤剂的效果。
将2至6岁有干性皮肤且有特应性倾向的儿童随机分为2组：第1组接受含有PIPJ和天然脂质的润肤剂，而第2组接受基于凡士林的润肤剂。在纳入研究时以及第4、12和16周评估皮肤状况和皮肤屏障的生物物理特性。
所有儿童的皮肤状况均有显著改善。比较两组，在第16周时，使用含有PIPJ的润肤剂治疗的儿童在前臂和前额处的角质层水合值显著更高，经表皮水分流失值显著更低。第2组在前臂和前额处的皮肤pH值显著降低；第1组显示出稳定的过程。
对有干性皮肤状况且有特应性倾向的儿童早期使用润肤剂进行干预，可能会在日常使用润肤剂期间改善他们的皮肤状况。基于PIPJ的配方可能有助于维持皮肤屏障的完整性。
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