注射小鼠重组肿瘤坏死因子后大鼠肝脏中α-1-酸性糖蛋白、载脂蛋白E、载脂蛋白B和β-肌动蛋白的mRNA变化
Changes in rat liver mRNA for alpha-1-acid-glycoprotein, apolipoprotein E, apolipoprotein B and beta-actin after mouse recombinant tumor necrosis factor injection.
作者信息
Delers F, Mangeney M, Raffa D, Vallet-Colom I, Daveau M, Tran-Quang N, Davrinches C, Chambaz J
机构信息
Laboratoire des proteines de la réaction inflamatoire, U.E.R. Biomédicale des Saints Pères, Paris, France.
出版信息
Biochem Biophys Res Commun. 1989 May 30;161(1):81-8. doi: 10.1016/0006-291x(89)91563-5.
Hybridization studies using specific cDNA probes have been used to determine the specific mRNA levels for apolipoproteins B and E, alpha 1 acid glycoprotein and beta actin in extracts of rat liver. Injection of rats with recombinant mouse tumor necrosis factor had led to a rapid increase in liver mRNA levels for alpha 1 acid glycoprotein (x 12) and for beta actin (x 2.5) whereas mRNA levels for Apolipoprotein B and E remained stable over the same period.
使用特定的cDNA探针进行杂交研究，已用于测定大鼠肝脏提取物中载脂蛋白B和E、α1酸性糖蛋白和β肌动蛋白的特定mRNA水平。给大鼠注射重组小鼠肿瘤坏死因子后，α1酸性糖蛋白（增加12倍）和β肌动蛋白（增加2.5倍）的肝脏mRNA水平迅速升高，而在此期间载脂蛋白B和E的mRNA水平保持稳定。
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