基于壳聚糖的复合水凝胶中替硝唑和茶碱的控释。
Controlled release of tinidazole and theophylline from chitosan based composite hydrogels.
机构信息
Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India.
Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India.
出版信息
Carbohydr Polym. 2014 Jun 15;106:109-20. doi: 10.1016/j.carbpol.2014.01.097. Epub 2014 Feb 5.
Several composite hydrogels were synthesized by free radical crosslink copolymerization of acrylic acid (AA) and N' methylene bis-acrylamide (MBA) in the presence of chitosan (CS). During polymerization CS was incorporated in situ in the crosslinked polyacrylic acid gel to produce composite hydrogels. The structure and properties of the hydrogels were characterized by FTIR, (13)C NMR, DTA-TGA, XRD, swelling and diffusion characteristic and also network parameters. The loading and the in vitro release behaviours of theophylline and tinidazole model drugs were studied with these hydrogels. The wt% of CS and MBA and pH of the medium was found to strongly influence the drug release behaviour of the gels. Accordingly, the release rate of these two drugs was much faster at pH of 7.6 than at pH 1.5.
几种复合水凝胶是通过在壳聚糖（CS）存在下，用自由基交联共聚丙烯酸（AA）和 N'亚甲基双丙烯酰胺（MBA）合成的。聚合过程中，CS 原位掺入到交联的聚丙烯酸凝胶中，生成复合水凝胶。通过 FTIR、（13）C NMR、DTA-TGA、XRD、溶胀和扩散特性以及网络参数对水凝胶的结构和性能进行了表征。用这些水凝胶研究了茶碱和替硝唑模型药物的负载和体外释放行为。发现 CS 和 MBA 的重量百分比和介质的 pH 值强烈影响凝胶的药物释放行为。因此，这两种药物在 pH 值为 7.6 时的释放速度比在 pH 值为 1.5 时快得多。
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