透明细胞牙源性癌中的EWSR1和ATF1重排：1例病例报告
EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: presentation of a case.
作者信息
Yancoskie Aaron E, Sreekantaiah Chandrika, Jacob Jessy, Rosenberg Amanda, Edelman Morris, Antonescu Cristina R, Fantasia John E
机构信息
Division of Oral and Maxillofacial Pathology, Department of Dental Medicine, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, USA.
Division of Cytogenetics and Molecular Pathology, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Oct;118(4):e115-8. doi: 10.1016/j.oooo.2014.02.004. Epub 2014 Feb 14.
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth decade. It is characterized by locally aggressive behavior and has the potential to metastasize. This tumor was recently reported to have a rearrangement of the Ewing sarcoma breakpoint region 1 gene (EWS RNA-binding protein 1, EWSR1) in 5 of 8 cases tested and of the activating transcription factor 1 gene (ATF1) in 1 case tested. We report a case of CCOC in the premolar area of the mandible in a 59-year-old woman. This case demonstrated the presence of both EWSR1 and ATF1 gene rearrangements by fluorescence in situ hybridization.
透明细胞牙源性癌（CCOC）是一种罕见的颌骨牙源性肿瘤，在下颌骨比上颌骨更常见，女性多见，发病高峰在第六个十年。它的特点是具有局部侵袭性，并有转移的可能。最近报道，在检测的8例中有5例该肿瘤存在尤因肉瘤断点区域1基因（EWS RNA结合蛋白1，EWSR1）重排，在检测的1例中有激活转录因子1基因（ATF1）重排。我们报告一例59岁女性下颌前磨牙区的CCOC病例。该病例通过荧光原位杂交显示同时存在EWSR1和ATF1基因重排。
Zotero 插件