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55 岁以上男性的降压药物对骨密度的长期影响。

Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years.

机构信息

Department of Oral and Maxillofacial Surgery, Turkey.

Department of Prosthodontics, School of Dentistry, University of Dicle, Diyarbakır, Turkey.

出版信息

Clin Interv Aging. 2014 Mar 27;9:509-13. doi: 10.2147/CIA.S60669. eCollection 2014.

Abstract

INTRODUCTION

In this study, we investigated the effects of long-term antihypertensive treatment with calcium channel blockers or beta blockers on the bone mineral density of maxilla, as determined by cone-beam computed tomography (CBCT).

MATERIAL AND METHODS

This retrospective study was conducted on CBCT images of men older than 55 years who had received different dental indications. Data were grouped into three categories according to the antihypertensive medication history of the patients: group A included patients who had been taking beta-blocker treatment for more than 5 years, group B included patients who had been taking calcium channel blocker treatment for more than 5 years, and the control group included patients who had never used any hypertensive medications before.

RESULTS

Statistically significant differences were observed between the beta blocker and calcium channel blocker groups.

CONCLUSION

In hypertension treatment, beta blockers may be preferred to calcium channel blockers in patients at high risk for osteoporosis and bone resorption.

摘要

简介

在这项研究中,我们通过锥形束计算机断层扫描(CBCT)研究了长期使用钙通道阻滞剂或β受体阻滞剂治疗对颌骨骨密度的影响。

材料和方法

本回顾性研究对 55 岁以上因不同口腔适应证而接受 CBCT 检查的男性进行,根据患者的降压药物史将数据分为三组:A 组包括服用β受体阻滞剂超过 5 年的患者,B 组包括服用钙通道阻滞剂超过 5 年的患者,对照组包括从未使用过任何降压药物的患者。

结果

β受体阻滞剂组和钙通道阻滞剂组之间存在统计学差异。

结论

在骨质疏松和骨质吸收风险较高的高血压患者中,β受体阻滞剂可能优于钙通道阻滞剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b9/3970919/67b43abbc929/cia-9-509Fig1.jpg

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