一种手性苯甲酰基硫脲-吡咯烷催化剂，用于酮对查耳酮的高对映选择性迈克尔加成。
A chiral benzoylthiourea-pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones.
机构信息
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, People's Republic of China; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, People's Republic of China.
出版信息
Bioorg Med Chem Lett. 2014 Jun 1;24(11):2517-20. doi: 10.1016/j.bmcl.2014.04.005. Epub 2014 Apr 13.
A benzoylthiourea-pyrrolidine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding products were obtained in high yields with high level of diastereoselectivities (up to 99:1 dr) and high level of enantioselectivities (up to 94% ee) under mild conditions.
开发了一种苯甲酰基硫脲-吡咯烷催化剂，用于酮与查耳酮的不对称迈克尔加成反应。在温和条件下，以高产率、高非对映选择性（高达 99:1 dr）和高对映选择性（高达 94%ee）获得了相应的产物。
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