PLCE1 抑制食管癌细胞中的 p53 表达。
PLCE1 suppresses p53 expression in esophageal cancer cells.
机构信息
Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.
出版信息
Cancer Invest. 2014 Jul;32(6):236-40. doi: 10.3109/07357907.2014.905588. Epub 2014 Apr 25.
The apoptotic mechanism dysfunction plays a critical role in cancer cell growth and escaping from cancer therapies; the underlying mechanisms are to be further elucidated. This study aims to investigate the role of phospholipase C epsilon 1 (PLCE1) in modulating the apoptosis mechanism in esophageal cancer (Eca) cells. The results showed that Eca cell lines, OE33 and CP-C cells expressed high levels of PLCE1. Knockdown of PLCE1 markedly increased 9.26 folds of the expression of p53 and 13.8 folds of the frequency of apoptotic CP-C cells via modulating the p53 promoter methylation.
凋亡机制功能障碍在癌细胞生长和逃避癌症治疗中起着关键作用；其潜在机制有待进一步阐明。本研究旨在探讨磷脂酶 C ɛ1 (PLCE1) 在调节食管癌(Eca)细胞凋亡机制中的作用。结果表明，Eca 细胞系 OE33 和 CP-C 细胞表达高水平的 PLCE1。通过调节 p53 启动子甲基化，PLCE1 敲低使 CP-C 细胞中 p53 的表达增加了 9.26 倍，凋亡频率增加了 13.8 倍。
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