在精神分裂症中使用附加经颅直流电刺激（tDCS）促进洞察力。
Insight facilitation with add-on tDCS in schizophrenia.
作者信息
Bose Anushree, Shivakumar Venkataram, Narayanaswamy Janardhanan C, Nawani Hema, Subramaniam Aditi, Agarwal Sri Mahavir, Chhabra Harleen, Kalmady Sunil V, Venkatasubramanian Ganesan
机构信息
The Schizophrenia Clinic, Department of Psychiatry & Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, India.
出版信息
Schizophr Res. 2014 Jun;156(1):63-5. doi: 10.1016/j.schres.2014.03.029. Epub 2014 Apr 24.
Impaired insight in schizophrenia patients has been linked with prefrontal deficits. In this open-label study, we examined for potential insight facilitation effects of add-on tDCS (with anodal stimulation of left DLPFC and cathodal stimulation over left temporo-parietal junction) in schizophrenia patients (N=21) with persistent auditory hallucinations despite adequate antipsychotic treatment. Following tDCS, there was a significant improvement in insight with concurrent significant reduction in auditory hallucination severity. Improvement in insight correlated significantly with improvement in severity of auditory hallucinations. These findings suggest improvement of insight with add-on tDCS in schizophrenia with persistent auditory hallucinations.
精神分裂症患者的洞察力受损与前额叶功能缺陷有关。在这项开放标签研究中，我们检测了在尽管接受了充分抗精神病药物治疗但仍存在持续性幻听的精神分裂症患者（N = 21）中，附加经颅直流电刺激（tDCS，阳极刺激左侧背外侧前额叶皮质，阴极刺激左侧颞顶联合区）对洞察力的潜在促进作用。经tDCS治疗后，洞察力有显著改善，同时幻听严重程度显著降低。洞察力的改善与幻听严重程度的改善显著相关。这些发现表明，附加tDCS可改善存在持续性幻听的精神分裂症患者的洞察力。
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