脂蛋白(a)极端水平对低密度脂蛋白胆固醇估计的显著影响。
Marked effects of extreme levels of lipoprotein(a) on estimation of low-density lipoprotein cholesterol.
作者信息
Saeedi Ramesh, Li Min, Allard Matt, Frohlich Jiri
机构信息
Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada.
出版信息
Clin Biochem. 2014 Aug;47(12):1098-9. doi: 10.1016/j.clinbiochem.2014.04.023. Epub 2014 May 2.
BACKGROUND
Low-density lipoprotein cholesterol (LDL-C) is usually calculated using the Friedewald equation. However, this calculation method does not account for the cholesterol associated with lipoprotein(a) [Lp(a)]. Using the Dahlen equation, Li et al. have shown a strong positive correlation between serum Lp(a) levels and overestimation of LDL-C levels.
OBJECTIVE
To determine how the extreme levels of Lp(a) influence the LDL-C calculation.
METHODS
We performed a retrospective chart review of the lipid profile and Lp(a) of 223 patients (men and women). LDL-C was calculated using the Friedewald equation. Lp(a) concentrations were measured by an ELISA. Other serum lipids were measured enzymatically by standard methodology. Corrected LDL-C was calculated using the Dahlen equation.
RESULTS
We found that this overestimation is very significant in individuals with extreme levels of Lp(a) (mean overestimation of 40% at Lp(a) >1200mg/L).
CONCLUSIONS
Calculated LDL-C is markedly overestimated in patients with extreme levels of Lp(a).
背景
低密度脂蛋白胆固醇（LDL-C）通常使用弗瑞德瓦尔德方程计算。然而，这种计算方法未考虑与脂蛋白（a）[Lp（a）]相关的胆固醇。Li等人使用达伦方程表明，血清Lp（a）水平与LDL-C水平的高估之间存在强正相关。
目的
确定Lp（a）的极端水平如何影响LDL-C的计算。
方法
我们对223例患者（男性和女性）的血脂谱和Lp（a）进行了回顾性图表审查。使用弗瑞德瓦尔德方程计算LDL-C。通过酶联免疫吸附测定法（ELISA）测量Lp（a）浓度。其他血清脂质通过标准方法进行酶法测量。使用达伦方程计算校正后的LDL-C。
结果
我们发现，在Lp（a）水平极高的个体中，这种高估非常显著（Lp（a）>1200mg/L时平均高估40%）。
结论
Lp（a）水平极高的患者中，计算出的LDL-C明显被高估。
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