骨关节炎的流行病学。

The epidemiology of osteoarthritis.

机构信息

Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Rheumatology Department, Royal North Shore Hospital and Kolling Institute, University of Sydney, Sydney, NSW, Australia.

出版信息

Best Pract Res Clin Rheumatol. 2014 Feb;28(1):5-15. doi: 10.1016/j.berh.2014.01.004.

DOI:10.1016/j.berh.2014.01.004

PMID:24792942

Abstract

Osteoarthritis (OA) is a leading cause of disability and its incidence is rising due to increasing obesity and an ageing population. Risk factors can be divided into person-level factors, such as age, sex, obesity, genetics, race/ethnicity and diet, and joint-level factors including injury, malalignment and abnormal loading of the joints. The interaction of these risk factors is complex and provides a challenge to the managing physician. The purpose of this review is to illustrate how each of these factors interact together to instigate incident OA as well as to outline the need for ongoing epidemiologic studies for the future prevention of both incident and progressive OA. It is only by understanding the impact of this disease and the modifiable risk factors that we will be able to truly target public health prevention interventions appropriately.

摘要

骨关节炎（OA）是导致残疾的主要原因，由于肥胖和人口老龄化，其发病率正在上升。危险因素可分为个体因素，如年龄、性别、肥胖、遗传、种族/民族和饮食，以及关节因素，包括损伤、关节对线不良和关节异常负荷。这些危险因素的相互作用很复杂，给主治医生带来了挑战。本综述的目的是说明这些因素如何相互作用引发新的 OA，以及概述未来预防新发病例和进行性 OA 所需的持续进行流行病学研究。只有了解这种疾病的影响和可改变的危险因素，我们才能真正有针对性地进行公共卫生预防干预。