金属类药物。
Metal-based drugs.
出版信息
Sci Prog. 2014;97(Pt 1):1-19. doi: 10.3184/003685014X13898980185076.
Abstract
Metals have been considered for millennia to have medicinal values. With the advent of modern medicine, many metal-based drugs have proven to be highly effective in the clinic. Many different metal ions have shown activity against a range of diseases. The unique electronic structure of transition metals offers great versatility, not always seen in organic drugs, in terms of the ability to tune the properties of a given molecule. This review gives a brief overview of the most established therapeutic metals, and their more common applications, such as platinum-based anticancer drugs. New developments within the field of metallodrugs and novel strategies being employed to improve methods of delivery, are also discussed.
摘要
千百年来，人们一直认为金属具有药用价值。随着现代医学的出现，许多基于金属的药物已被证明在临床上非常有效。许多不同的金属离子对一系列疾病都表现出了活性。过渡金属独特的电子结构提供了很大的多功能性，这在有机药物中并不常见，因为它能够调整给定分子的性质。本文简要概述了最常用的治疗性金属及其更常见的应用，如铂类抗癌药物。本文还讨论了金属药物领域的新进展以及为改善药物输送方法而采用的新策略。
相似文献
1
Metal-based drugs.
Sci Prog. 2014;97(Pt 1):1-19. doi: 10.3184/003685014X13898980185076.
2
Platinum anticancer drugs and photochemotherapeutic agents: recent advances and future developments.
Sci Prog. 2014;97(Pt 1):20-40. doi: 10.3184/003685014X13904811808460.
3
New metal complexes as potential therapeutics.
Curr Opin Chem Biol. 2003 Aug;7(4):481-9. doi: 10.1016/s1367-5931(03)00081-4.
4
Editorial: Throwing Light on Recent Advances on Metallodrugs: From Deemed Poisons to a Striking Hope for the Future.
Curr Med Chem. 2018 Feb 12;25(4):434-436. doi: 10.2174/092986732504180212164536.
5
Water-soluble organometallic analogues of oxaliplatin with cytotoxic and anticlonogenic activity.
ChemMedChem. 2010 Jan;5(1):46-51. doi: 10.1002/cmdc.200900412.
6
A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy.
Org Biomol Chem. 2019 May 29;17(21):5367-5374. doi: 10.1039/c9ob00698b.
7
Unusual DNA binding modes for metal anticancer complexes.
Biochimie. 2009 Oct;91(10):1198-211. doi: 10.1016/j.biochi.2009.03.017. Epub 2009 Apr 1.
8
Non-classical structures among current platinum complexes with potential as antitumor drugs.
Curr Top Med Chem. 2011;11(21):2613-22. doi: 10.2174/156802611798040723.
9
Next-generation anticancer metallodrugs.
Curr Top Med Chem. 2012;12(3):219-35. doi: 10.2174/156802612799078964.
10
Photoswitching the cytotoxic properties of platinum(II) compounds.
Angew Chem Int Ed Engl. 2015 Apr 7;54(15):4561-5. doi: 10.1002/anie.201412157. Epub 2015 Feb 16.
引用本文的文献
1
Development of Half-Sandwich Ru, Os, Rh, and Ir Complexes Bearing the Pyridine-2-ylmethanimine Bidentate Ligand Derived from 7-Chloroquinazolin-4(3H)-one with Enhanced Antiproliferative Activity.
ACS Omega. 2024 Apr 13;9(16):18224-18237. doi: 10.1021/acsomega.3c10482. eCollection 2024 Apr 23.
2
Exploring the in vitro anticancer activities of Re(I) picolinic acid and its fluorinated complex derivatives on lung cancer cells: a structural study.
J Biol Inorg Chem. 2023 Feb;28(1):29-41. doi: 10.1007/s00775-022-01971-2. Epub 2022 Dec 4.
3
Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer.
Molecules. 2022 Jul 19;27(14):4597. doi: 10.3390/molecules27144597.
4
Ru(ii)arene(N^N bpy/phen)-based RAPTA complexes for anti-tumour activity in human glioblastoma cancer cell lines and toxicity studies in a zebrafish model.
RSC Adv. 2022 Jun 29;12(29):18911-18922. doi: 10.1039/d2ra02677e. eCollection 2022 Jun 22.
5
In Vitro Evaluation of the Potential Pharmacological Activity and Molecular Targets of New Benzimidazole-Based Schiff Base Metal Complexes.
Antibiotics (Basel). 2021 Jun 16;10(6):728. doi: 10.3390/antibiotics10060728.
6
Ionic gold demonstrates antimicrobial activity against Pseudomonas aeruginosa strains due to cellular ultrastructure damage.
Arch Microbiol. 2021 Aug;203(6):3015-3024. doi: 10.1007/s00203-021-02270-1. Epub 2021 Mar 29.
7
Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent.
Metabolites. 2021 Feb 17;11(2):114. doi: 10.3390/metabo11020114.
8
Research Progress in the Modification of Quercetin Leading to Anticancer Agents.
Molecules. 2017 Jul 29;22(8):1270. doi: 10.3390/molecules22081270.
9
Antiproliferative effects of ruthenium-based nucleolipidic nanoaggregates in human models of breast cancer in vitro: insights into their mode of action.
Sci Rep. 2017 Mar 28;7:45236. doi: 10.1038/srep45236.
10
Cytotoxicity of Titanate-Calcium Complexes to MC3T3 Osteoblast-Like Cells.
Biomed Res Int. 2016;2016:7895182. doi: 10.1155/2016/7895182. Epub 2016 Dec 1.
本文引用的文献
1
Nucleotide Platination Induced by Visible Light.
Angew Chem Int Ed Engl. 1999 May 17;38(10):1460-1463. doi: 10.1002/(SICI)1521-3773(19990517)38:10<1460::AID-ANIE1460>3.0.CO;2-Z.
2
Metals in Medicine.
Angew Chem Int Ed Engl. 1999 Jun 1;38(11):1512-1531. doi: 10.1002/(SICI)1521-3773(19990601)38:11<1512::AID-ANIE1512>3.0.CO;2-Y.
3
Photonic crystal fibres for chemical sensing and photochemistry.
Chem Soc Rev. 2013 Nov 21;42(22):8629-48. doi: 10.1039/c3cs60128e.
4
Ligands affecting silver antimicrobial efficacy on Listeria monocytogenes and Salmonella enterica.
Food Chem. 2013 Aug 15;139(1-4):281-8. doi: 10.1016/j.foodchem.2013.01.015. Epub 2013 Jan 23.
5
Reduction of quinones by NADH catalyzed by organoiridium complexes.
Angew Chem Int Ed Engl. 2013 Apr 8;52(15):4194-7. doi: 10.1002/anie.201300747. Epub 2013 Mar 7.
6
Advance in photosensitizers and light delivery for photodynamic therapy.
Clin Endosc. 2013 Jan;46(1):7-23. doi: 10.5946/ce.2013.46.1.7. Epub 2013 Jan 31.
7
Targeted delivery of platinum-based anticancer complexes.
Curr Opin Chem Biol. 2013 Apr;17(2):175-88. doi: 10.1016/j.cbpa.2013.01.004. Epub 2013 Feb 7.
8
The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway.
J Med Chem. 2013 Feb 14;56(3):1291-300. doi: 10.1021/jm3017442. Epub 2013 Jan 31.
9
Competitive formation of both long-range 5'-5' and short-range antiparallel 3'-3' DNA interstrand cross-links by a trinuclear platinum complex on binding to a 10-mer duplex.
Dalton Trans. 2013 Mar 7;42(9):3181-7. doi: 10.1039/c2dt32079g. Epub 2012 Nov 19.
10
Targeting and delivery of platinum-based anticancer drugs.
Chem Soc Rev. 2013 Jan 7;42(1):202-24. doi: 10.1039/c2cs35259a. Epub 2012 Oct 5.
Zotero 插件