波兰北部一个以城市人口为主的成年人群体在冬季出现维生素D缺乏的情况。

Vitamin D deficiency during winter months among an adult, predominantly urban, population in Northern Poland.

作者信息

Kmieć Piotr, Żmijewski Michał, Waszak Przemysław, Sworczak Krzysztof, Lizakowska-Kmieć Maria

出版信息

Endokrynol Pol. 2014;65(2):105-13. doi: 10.5603/EP.2014.0015.

DOI:10.5603/EP.2014.0015

PMID:24802733

Abstract

INTRODUCTION

Vitamin D is vital in the regulation of the calcium-phosphate metabolism, has a direct impact on the musculoskeletal system, and also affects numerous other systems. Widespread vitamin D deficiency and its detrimental effect on health have been reported globally. Data concerning vitamin D status in Polish adult population is scarce.

MATERIAL AND METHODS

Ambulatory patients of an outpatient clinic in Gdańsk were included in the study. Serum concentrations of 25(OH) D, parathyroid hormone (PTH), alkaline phosphatase (ALP), calcium and phosphorus were determined. In a questionnaire declared UVB exposure, dietary vitamin D and calcium intake, and health status of the subjects were assessed. Non- and parametric tests, logistic regression and population attributable risk were applied in data analysis.

RESULTS

448 adults were examined from February to mid-April 2012, 305 women and 143 men, aged 19 to 86 (mean 46.3 ± 14.9 years). Mean 25-hydroxyvitamin D concentration was 14.3 ± 6.6 ng/mL. 84.4% of subjects were vitamin D deficient (25(OH)D < 20 ng/mL); 13.2% presented insufficient (20-30 ng/mL), and 2.5% (or 11 subjects) sufficient 25(OH)D concentrations. Significantly higher 25(OH)D concentrations were found in subjects who reported more UVB exposure, supplemented vitamin D orally and those who declared more physical activity. 21% of subjects had elevated serum PTH concentration (i.e. > 62 pg/mL); mean parathormone was 48.6 ± 25.2 pg/mL. A linear correlation was found between the logarithm of PTH and logarithm of 25(OH)D concentrations (r = -0.21, p < 0.001).

CONCLUSIONS

Results obtained here demonstrate the necessity of implementing a monitoring and prophylaxis programme of vitamin D deficiency in Poland.

摘要

引言

维生素D在钙磷代谢调节中至关重要，对肌肉骨骼系统有直接影响，还会影响许多其他系统。全球范围内都报道了普遍存在的维生素D缺乏及其对健康的有害影响。关于波兰成年人群维生素D状况的数据很少。

材料与方法

格但斯克一家门诊诊所的门诊患者被纳入研究。测定血清25(OH)D、甲状旁腺激素（PTH）、碱性磷酸酶（ALP）、钙和磷的浓度。通过问卷调查评估受试者宣称的紫外线B暴露情况、膳食维生素D和钙摄入量以及健康状况。数据分析采用非参数检验、逻辑回归和人群归因风险分析。

结果

2012年2月至4月中旬对448名成年人进行了检查，其中305名女性和143名男性，年龄在19至86岁之间（平均46.3±14.9岁）。25-羟维生素D的平均浓度为14.3±6.6 ng/mL。84.4%的受试者维生素D缺乏（25(OH)D<20 ng/mL）；13.2%的受试者维生素D水平不足（20 - 30 ng/mL），2.5%（即11名受试者）的25(OH)D浓度充足。报告紫外线B暴露更多、口服补充维生素D以及宣称身体活动更多的受试者，其25(OH)D浓度明显更高。21%的受试者血清PTH浓度升高（即>62 pg/mL）；甲状旁腺激素的平均值为48.6±25.2 pg/mL。发现PTH的对数与25(OH)D浓度的对数之间存在线性相关性（r = -0.21，p<0.001）。