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5毫克/毫升布比卡因原液给药后30分钟的腹围、脊柱长度及蛛网膜下腔麻醉平面扩散情况。

Abdominal girth, vertebral column length, and spread of spinal anesthesia in 30 minutes after plain bupivacaine 5 mg/mL.

作者信息

Zhou Qing-He, Xiao Wang-Pin, Shen Ying-Yan

机构信息

From the Department of Anesthesiology, the Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.

出版信息

Anesth Analg. 2014 Jul;119(1):203-206. doi: 10.1213/ANE.0000000000000199.

Abstract

BACKGROUND

The spread of spinal anesthesia is highly unpredictable. In patients with increased abdominal girth and short stature, a greater cephalad spread after a fixed amount of subarachnoidally administered plain bupivacaine is often observed. We hypothesized that there is a strong correlation between abdominal girth/vertebral column length and cephalad spread.

METHODS

Age, weight, height, body mass index, abdominal girth, and vertebral column length were recorded for 114 patients. The L3-L4 interspace was entered, and 3 mL of 0.5% plain bupivacaine was injected into the subarachnoid space. The cephalad spread (loss of temperature sensation and loss of pinprick discrimination) was assessed 30 minutes after intrathecal injection. Linear regression analysis was performed for age, weight, height, body mass index, abdominal girth, vertebral column length, and the spread of spinal anesthesia, and the combined linear contribution of age up to 55 years, weight, height, abdominal girth, and vertebral column length was tested by multiple regression analysis.

RESULTS

Linear regression analysis showed that there was a significant univariate correlation among all 6 patient characteristics evaluated and the spread of spinal anesthesia (all P < 0.039) except for age and loss of temperature sensation (P > 0.068). Multiple regression analysis showed that abdominal girth and the vertebral column length were the key determinants for spinal anesthesia spread (both P < 0.0001), whereas age, weight, and height could be omitted without changing the results (all P > 0.059, all 95% confidence limits < 0.372).

CONCLUSIONS

Multiple regression analysis revealed that the combination of a patient's 5 general characteristics, especially abdominal girth and vertebral column length, had a high predictive value for the spread of spinal anesthesia after a given dose of plain bupivacaine.

摘要

背景

脊髓麻醉的扩散高度不可预测。在腹围增加和身材矮小的患者中,蛛网膜下腔注射一定量的普通布比卡因后,常常观察到更高的头向扩散。我们假设腹围/脊柱长度与头向扩散之间存在强相关性。

方法

记录114例患者的年龄、体重、身高、体重指数、腹围和脊柱长度。进入L3-L4椎间隙,将3毫升0.5%的普通布比卡因注入蛛网膜下腔。在鞘内注射后30分钟评估头向扩散(温度感觉丧失和针刺觉丧失)。对年龄、体重、身高、体重指数、腹围、脊柱长度和脊髓麻醉扩散进行线性回归分析,并通过多元回归分析测试年龄达55岁、体重、身高、腹围和脊柱长度的综合线性贡献。

结果

线性回归分析显示,除年龄与温度感觉丧失外(P>0.068),所评估的所有6项患者特征与脊髓麻醉扩散之间均存在显著的单变量相关性(所有P<0.039)。多元回归分析显示,腹围和脊柱长度是脊髓麻醉扩散的关键决定因素(两者P<0.0001),而年龄、体重和身高在不改变结果的情况下可以省略(所有P>0.059,所有95%置信区间<0.372)。

结论

多元回归分析显示,患者的5项一般特征,尤其是腹围和脊柱长度的组合,对给予一定剂量普通布比卡因后脊髓麻醉的扩散具有较高的预测价值。

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