通过光谱域光学相干断层扫描对小鼠器官进行病理分类的散射系数。

Scattering coefficients of mice organs categorized pathologically by spectral domain optical coherence tomography.

作者信息

Zhang Q Q, Wu X J, Wang C, Zhu S W, Wang Y L, Gao Bruce Z, Yuan X-C

机构信息

Institute of Modern Optics, Key Laboratory of Optical Information Science & Technology, Ministry of Education of China, Nankai University, Tianjin 300071, China.

Nankai University Affiliated Hospital, Tianjin 300121, China.

出版信息

Biomed Res Int. 2014;2014:471082. doi: 10.1155/2014/471082. Epub 2014 Apr 13.

DOI:10.1155/2014/471082

PMID:24822213

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4005150/

Abstract

Differences in tissue density cause a variety of scattering coefficients. To quantify optical coherence tomography (OCT) images for diagnosis, the tissue's scattering coefficient is estimated by curve fitting the OCT signals to a confocal single backscattering mode. The results from a group of 30 mice show that the scattering coefficients of bone, skin, liver, brain, testis, and spleen can be categorized into three groups: a scattering coefficient between 1.947 and 2.134 mm(-1): bone and skin; a scattering coefficient between 1.303 and 1.461 mm(-1): liver and brain; a scattering coefficient between 0.523 and 0.634 mm(-1): testis and spleen. The results indicate that the scattering coefficient is tissue specific and could be used in tissue diagnosis.

摘要

组织密度的差异会导致多种散射系数。为了对光学相干断层扫描（OCT）图像进行量化以用于诊断，通过将OCT信号拟合到共焦单背散射模式来估计组织的散射系数。一组30只小鼠的结果表明，骨骼、皮肤、肝脏、大脑、睾丸和脾脏的散射系数可分为三组：散射系数在1.947至2.134 mm⁻¹之间：骨骼和皮肤；散射系数在1.303至1.461 mm⁻¹之间：肝脏和大脑；散射系数在0.523至0.634 mm⁻¹之间：睾丸和脾脏。结果表明，散射系数具有组织特异性，可用于组织诊断。