Rose M, Knüchel R
Institut für Pathologie, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland.
Urologe A. 2014 Jun;53(6):802-16. doi: 10.1007/s00120-014-3465-9.
This overview mainly focuses on the topic of epithelial tumors (carcinomas) because urological tumors are generally of this type. The importance of the topic is reflected by the fact that patients rarely die of the primary tumor, but the majority die of metastases that cause life-threatening situations. More recent findings show that treatment decisions should be based on the metastasis site and less on the tumor's tissue of origin. Given the progression of clinical oncology toward individualized medicine, a better understanding of the biology of metastases is therefore acute and includes some important challenges.
本综述主要聚焦于上皮性肿瘤(癌)这一主题,因为泌尿系统肿瘤通常属于此类。该主题的重要性体现在患者很少死于原发性肿瘤,而大多数死于导致危及生命情况的转移瘤这一事实。最新研究结果表明,治疗决策应基于转移部位,而非肿瘤的起源组织。鉴于临床肿瘤学朝着个体化医学的发展,因此迫切需要更好地了解转移瘤的生物学特性,这其中还包括一些重要挑战。