Camara Makhtar, Dieng Assane, Boye Cheikh Saad Bouh
Laboratory of Bacteriology-Virology, Centre Hospitalier Universitaire Le Dantec, Cheikh Anta DIOP University, Dakar, Senegal.
Microbiol Insights. 2013 Oct 29;6:71-5. doi: 10.4137/MBI.S12996. eCollection 2013.
Group A Streptococcus (GAS) is one of the major causes of respiratory tract infections. The objectives of this study were to identify isolates of S. pyogenes obtained from respiratory tract infections, and to assess their susceptibility to several antibiotics. A total of 40 strains were isolated and their susceptibility to 17 antibiotics was tested using a standard disk diffusion method. The minimum inhibitory concentrations (MICs) were determined using the E-test. All isolates were sensitive to β-lactam antibiotics including penicillin, amoxicillin, and cephalosporins. Macrolides remain active with the exception of spiramycin, which showed reduced susceptibility. Out of the 40 isolates, 100% of the isolates were resistant to tetracycline. Interestingly, isolates were sensitive to chloramphenicol, teicoplanin, vancomycine, and levofloxacin, providing potential alternative choices of treatment against infections with S. pyogenes.
A组链球菌(GAS)是呼吸道感染的主要病因之一。本研究的目的是鉴定从呼吸道感染中分离出的化脓性链球菌菌株,并评估它们对几种抗生素的敏感性。共分离出40株菌株,并使用标准纸片扩散法检测了它们对17种抗生素的敏感性。使用E-test测定最低抑菌浓度(MIC)。所有分离株对包括青霉素、阿莫西林和头孢菌素在内的β-内酰胺类抗生素敏感。除螺旋霉素敏感性降低外,大环内酯类抗生素仍具有活性。在40株分离株中,100%的分离株对四环素耐药。有趣的是,分离株对氯霉素、替考拉宁、万古霉素和左氧氟沙星敏感,为治疗化脓性链球菌感染提供了潜在的替代治疗选择。