De Basso Rachel, Hedblad Bo, Carlson Joyce, Persson Margaretha, Ostling Gerd, Länne Toste
Department of Clinical Physiology, Division of Medical Diagnostics, Jönköping Hospital, Jönköping, Sweden.
Clin Exp Pharmacol Physiol. 2014 Sep;41(9):637-42. doi: 10.1111/1440-1681.12259.
Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The FBN1 genotype was characterized in 5765 subjects (2424 men, 3341 women; age 45-69 years) recruited from the Malmö Diet and Cancer Study Cardiovascular Cohort, Sweden. Plaque occurrence and intima-media thickness (IMT) of the carotid artery were assessed by ultrasound. The incidence of first cardiovascular events (myocardial infarction and stroke) and cause-specific mortality were monitored over a mean follow-up period of 13.2 years. The most common FBN1 genotypes were 2/2, 2/3 and 2/4, which accounted for 92.2% (n = 5317) of subjects. There were no differences between the three genotypes regarding age, blood pressure, glucose, lipids, smoking habits, common carotid artery diameter and intima-media thickness in men and women. The presence of plaque in the carotid artery was higher in men with the 2/3 genotype compared with the 2/2 and 2/4 genotypes (55% vs 46% and 50%, respectively; P = 0.007). No similar differences were observed in women. No significant relationship was observed between FBN1 genotypes and the incidence of cardiovascular disease or all-cause mortality. The increased prevalence of plaque in the carotid artery of middle-aged men with the FBN1 2/3 genotype indicates pathological arterial wall remodelling with a more pronounced atherosclerotic burden.
原纤蛋白-1（FBN1）是血管壁的重要组成部分，早期研究表明FBN1 2/3基因型对男性血压及主动脉僵硬度有影响。本研究旨在确定FBN1 2/3基因型是否与中年受试者颈动脉斑块的存在以及心血管疾病的发病率和死亡率相关。对从瑞典马尔默饮食与癌症研究心血管队列中招募的5765名受试者（2424名男性，3341名女性；年龄45 - 69岁）进行FBN1基因型分析。通过超声评估颈动脉斑块的发生情况和内膜中层厚度（IMT）。在平均13.2年的随访期内监测首次心血管事件（心肌梗死和中风）的发生率及特定病因死亡率。最常见的FBN1基因型为2/2、2/3和2/4，占受试者的92.2%（n = 5317）。在年龄、血压、血糖、血脂、吸烟习惯、颈总动脉直径和内膜中层厚度方面，男性和女性的这三种基因型之间均无差异。与2/2和2/4基因型相比，2/3基因型男性颈动脉斑块的发生率更高（分别为55%、46%和50%；P = 0.007）。在女性中未观察到类似差异。未观察到FBN1基因型与心血管疾病发病率或全因死亡率之间存在显著关系。FBN1 2/3基因型中年男性颈动脉斑块患病率增加表明动脉壁发生病理性重塑，动脉粥样硬化负担更明显。
