Ghosh Saptarshi, Kotne Sivasankar, Ananda Rao P B, Turlapati S P V, Kumar Soren Dillip
Department of Radiotherapy, GSL Medical College & General Hospital, Opposite to Swatantra Hospital, Near Kambala Park, Rajahmundry, Andhra Pradesh 533105, India.
Department of Pathology, GSL Medical College & General Hospital, Rajahmundry, Andhra Pradesh 533296, India.
Case Rep Dermatol Med. 2014;2014:205638. doi: 10.1155/2014/205638. Epub 2014 Mar 4.
Lichen planus is a benign disorder characterized by an itchy, noninfectious skin rash. Though lichen planus is a common papulosquamous disorder affecting about 1-2% of the population, neoplastic transformation of cutaneous lichen planus lesions occurs very rarely and should be borne in mind while treating nonhealing longstanding lesions of lichen planus. Studies suggest an estimated 0.3-3% risk of malignancy in patients with oral lichen planus, however, cutaneous lichen planus does not carry an increased risk of malignant degeneration. We present a case of a 36-year-old male with a 10-year-long history of hypertrophic lichen planus who presented with a nonhealing ulcer in the left popliteal fossa. The patient underwent wide local excision with superficial skin grafting. Postoperative histopathological examination revealed verrucous squamous cell carcinoma complicating lichen planus. In view of underlying structure involvement, adjuvant radiation therapy was given. This case is being reported to emphasize the infrequent possibility of development of malignancy in cutaneous lichen planus, especially if it presents as a longstanding, nonhealing, itchy lesion with patchy areas of depigmentation in the lower limbs.
扁平苔藓是一种良性疾病,其特征为伴有瘙痒的非感染性皮疹。尽管扁平苔藓是一种常见的丘疹鳞屑性疾病,影响约1%-2%的人群,但皮肤扁平苔藓病变的肿瘤性转化非常罕见,在治疗长期不愈合的扁平苔藓病变时应予以考虑。研究表明,口腔扁平苔藓患者发生恶性肿瘤的风险估计为0.3%-3%,然而,皮肤扁平苔藓并不会增加恶性退变的风险。我们报告一例36岁男性患者,有10年肥厚性扁平苔藓病史,左腘窝出现一个长期不愈合的溃疡。患者接受了广泛局部切除并进行了表层皮肤移植。术后组织病理学检查显示疣状鳞状细胞癌合并扁平苔藓。鉴于潜在结构受累,给予了辅助放疗。报告此病例是为了强调皮肤扁平苔藓发生恶性肿瘤的可能性很小,尤其是当它表现为长期不愈合、瘙痒且下肢有片状色素脱失区域的病变时。