维生素D受体BsmI基因多态性与2型糖尿病风险的关联
Association of vitamin D receptor BsmI gene polymorphism with the risk of type 2 diabetes mellitus.
作者信息
Zhu Bo, Zhao Hui-Liu, Ou Chao, Huang Ling-Sha, Li Pei-Zhang, Lao Ming
机构信息
Department of Clinical laboratory, The Affiliated Tumor Hospital of Guangxi Medical University , NanNing, Guangxi Province , China.
出版信息
J Recept Signal Transduct Res. 2014 Dec;34(6):458-62. doi: 10.3109/10799893.2014.919592. Epub 2014 May 19.
Relationship between vitamin D receptor (VDR) BsmI (rs1544410) gene polymorphism and the type 2 diabetes mellitus (T2DM) susceptibility is still conflicting at present. This meta-analysis was conducted to assess the association between VDR BsmI gene polymorphism and the risk of T2DM. The association studies were identified from PubMed, and Cochrane Library on 1 January 2014, and eligible investigations were included and synthesized using meta-analysis method. Eleven reports were recruited into this meta-analysis for the association of VDR BsmI gene polymorphism with T2DM susceptibility. In overall populations, B allele, BB genotype and bb genotype were not associated with T2DM risk. VDR BsmI gene polymorphism was also not associated with the T2DM risk in Asians and Caucasians. In conclusion, VDR BsmI gene polymorphism was also not associated with T2DM risk in overall populations, Asians and Caucasians. However, more studies should be conducted to confirm it.
维生素D受体（VDR）BsmI（rs1544410）基因多态性与2型糖尿病（T2DM）易感性之间的关系目前仍存在争议。本荟萃分析旨在评估VDR BsmI基因多态性与T2DM风险之间的关联。通过检索2014年1月1日的PubMed和Cochrane图书馆来确定相关的关联研究，并纳入符合条件的研究采用荟萃分析方法进行综合分析。11篇报告被纳入本荟萃分析，用于研究VDR BsmI基因多态性与T2DM易感性的关联。在总体人群中，B等位基因、BB基因型和bb基因型与T2DM风险无关。VDR BsmI基因多态性在亚洲人和高加索人中也与T2DM风险无关。总之，VDR BsmI基因多态性在总体人群、亚洲人和高加索人中也与T2DM风险无关。然而，需要进行更多的研究来证实这一点。
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