The Brain Tumor Center, The University of Chicago, Chicago, IL, USA.
Expert Rev Neurother. 2014 Jun;14(6):651-60. doi: 10.1586/14737175.2014.917964.
Many different experimental molecular therapeutic approaches have been evaluated in an attempt to treat brain cancer. However, despite the success of these experimental molecular therapies, research has shown that the specific and efficient delivery of therapeutic agents to tumor cells is a limitation. In this regard, cell carrier systems have garnered significant attraction due to their capacity to be loaded with therapeutic agents and carry them specifically to tumor sites. Furthermore, cell carriers can be genetically modified to express therapeutic agents that can directly eradicate cancerous cells or can modulate tumor microenvironments. This review describes the current state of cell carriers, their use as vehicles for the delivery of therapeutic agents to brain tumors, and future directions that will help overcome the present obstacles to cell carrier mediated therapy for brain cancer.
许多不同的实验性分子治疗方法已被评估，试图治疗脑癌。然而，尽管这些实验性分子疗法取得了成功，但研究表明，将治疗剂特异性和有效地递送到肿瘤细胞是一个限制。在这方面，细胞载体系统因其能够装载治疗剂并将其专门递送到肿瘤部位而引起了极大的关注。此外，细胞载体可以进行基因修饰以表达可以直接消灭癌细胞或可以调节肿瘤微环境的治疗剂。本综述描述了细胞载体的现状、它们作为将治疗剂递送到脑肿瘤的载体的用途以及未来的方向，这些方向将有助于克服细胞载体介导的脑癌治疗目前存在的障碍。
