中国人群中血清淀粉样蛋白A1（SAA1，rs12218）基因多态性与心肌梗死的关联
Association of genetic polymorphisms of SAA1 (rs12218) with myocardial infarction in a Chinese population.
作者信息
Wang B Y, Hang J Y, Zhong Y, Tan S J
机构信息
Department of Geriatrics, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Department of Cardiology, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
出版信息
Genet Mol Res. 2014 May 9;13(2):3693-6. doi: 10.4238/2014.May.9.13.
Previous studies suggested that genetic polymorphisms of serum amyloid A (SAA) were associated with carotid atherosclerosis. However, the relationship between genetic polymorphisms of SAA and myocardial infarction (MI) remains unclear. In the present study, we analyzed a polymorphism (rs12218) in the SAA1 gene in 840 MI patients and 840 healthy subjects by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We found that the rs12218 CC+CT genotype was more frequent among MI patients than among healthy controls (61.1% vs 41.9%; P < 0.001). Multivariate regression analysis showed that after adjustment for gender, age, smoking, drinking, hypertension, and diabetes, the difference remained significant (P < 0.001, odds ratio = 3.332, 95% confidence interval = 1.781-9.231). Therefore, we concluded that genetic polymorphisms of SAA1 may be a genetic marker of MI in the Chinese population.
先前的研究表明，血清淀粉样蛋白A（SAA）的基因多态性与颈动脉粥样硬化有关。然而，SAA基因多态性与心肌梗死（MI）之间的关系仍不清楚。在本研究中，我们采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，分析了840例MI患者和840例健康受试者SAA1基因中的一个多态性位点（rs12218）。我们发现，rs12218 CC+CT基因型在MI患者中的频率高于健康对照者（61.1%对41.9%；P<0.001）。多因素回归分析显示，在对性别、年龄、吸烟、饮酒、高血压和糖尿病进行校正后，差异仍然显著（P<0.001，比值比=3.332，95%置信区间=1.781-9.231）。因此，我们得出结论，SAA1基因多态性可能是中国人群MI的一个遗传标志物。
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