来自蝉花真菌子囊果和虫体部分的环缩肽。
Cyclodepsipeptides from the ascocarps and insect-body portions of fungus Cordyceps cicadae.
作者信息
Wang Jing, Zhang Dong-Mei, Jia Jun-Feng, Peng Qun-Long, Tian Hai-Yan, Wang Lei, Ye Wen-Cai
机构信息
Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China.
Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou, PR China.
出版信息
Fitoterapia. 2014 Sep;97:23-7. doi: 10.1016/j.fitote.2014.05.010. Epub 2014 May 24.
A new cyclodepsipeptide cordycecin A (1), together with four known ones beauvericin E (2), beauvericin J (3), beauvericin (4), and beauvericin A (5) was isolated from the ascocarps and insect-body portions of fungus Cordyceps cicadae. Their structures were identified by NMR and MS analyses. The absolute configuration of 1 was confirmed by crystal X-ray diffraction. Compounds 2-5 exhibited a significant inhibitory effect on HepG2 and HepG2/ADM cells with IC50 values ranging from 2.40±0.37 to 14.48±1.68 μM. Interestingly, compounds 3-5 showed cytotoxic activity against multiple drug resistant HepG2 cell line (HepG2/ADM) with IC50 value 25-fold more sensitive to doxorubicin.
从蝉花真菌的子囊果和虫体部分分离出一种新的环缩肽虫草菌素A（1），以及四种已知的环缩肽：白僵菌素E（2）、白僵菌素J（3）、白僵菌素（4）和白僵菌素A（5）。通过核磁共振（NMR）和质谱（MS）分析确定了它们的结构。通过晶体X射线衍射确定了1的绝对构型。化合物2 - 5对HepG2和HepG2/ADM细胞表现出显著的抑制作用，IC50值范围为2.40±0.37至14.48±1.68 μM。有趣的是，化合物3 - 5对多药耐药的HepG2细胞系（HepG2/ADM）显示出细胞毒性活性，其IC50值对阿霉素的敏感性高25倍。
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