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[一家儿科医院中患有和未患有代谢综合征的肥胖儿童的特征分析]

[Characterization of obese children with and without metabolic syndrome in a pediatric hospital].

作者信息

Ortega-Cortés Rosa, Hurtado-López Erika F, López-Beltrán Ana L, Trujillo-Trujillo Xóchitl A R, Tlacuilo-Parra José, Colunga-Rodríguez Cecilia

机构信息

Servicio de Urgencias Pediátricas, Hospital de Pediatría, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2014;52 Suppl 1:S48-56.

Abstract

BACKGROUND

The alterations caused by metabolic syndrome (MS) arise progressively throughout the years, but they can start at a pediatric age. The objective of this paper was to evaluate the biochemical and clinical characteristics of obese children with or without MS.

METHODS

Descriptive cross-sectional study, in which we analyzed, according to the 2010 classification of the Centers for Disease Control and Prevention (CDC), 103 obese children between 10 and 15 years from an endocrinology service. The variables were weight, size, body mass index (BMI), waist circumference (WC), glucose, HDL cholesterol, triglycerides, blood pressure, insulin, and HOMA. Means were compared statistically with Student's t test, and Mann-Whitney U.

RESULTS

Of 103 patients, 55 showed criteria for MS (53.3 %) and 48 incomplete criteria for MS (46.6 %). In the group without MS, 60.4 and 64.5 % showed insulin resistance and hyperinsulinemia, respectively. In all the group, 28.1 % showed arterial hypertension, and 23.3 % prehypertension. With regards to the means of other parameters that does not belong to the MS, we obtained weight (p = 0.008), BMI (p = 0.009), insulin (p = 0.027) and HOMA (p = 0.023). More than 60 % showed pre-diabetes and almost 50 % blood pressure alterations.

CONCLUSION

It is urgent to perform a screening in obese children, as well as an awareness campaign in mass media, in order to spread the gravity of the problem and trigger the search of medical help, and of health professionals to establish their diagnosis.

摘要

背景

代谢综合征(MS)所引发的改变会随时间逐渐显现,但也可能始于儿童时期。本文旨在评估患有或未患有MS的肥胖儿童的生化及临床特征。

方法

描述性横断面研究,依据美国疾病控制与预防中心(CDC)2010年的分类标准,我们分析了来自内分泌科的103名10至15岁的肥胖儿童。变量包括体重、身高、体重指数(BMI)、腰围(WC)、血糖、高密度脂蛋白胆固醇、甘油三酯、血压、胰岛素及稳态模型评估胰岛素抵抗指数(HOMA)。采用学生t检验和曼-惠特尼U检验对均值进行统计学比较。

结果

103例患者中,55例符合MS标准(53.3%),48例不符合MS完整标准(46.6%)。在未患MS的组中,分别有60.4%和64.5%的儿童表现出胰岛素抵抗和高胰岛素血症。在所有组中,28.1%的儿童患有动脉高血压,23.3%的儿童患有高血压前期。关于其他不属于MS的参数均值,我们得出体重(p = 0.008)、BMI(p = 0.009)、胰岛素(p = 0.027)和HOMA(p = 0.023)。超过60%的儿童表现出糖尿病前期,近50%的儿童存在血压改变。

结论

迫切需要对肥胖儿童进行筛查,并开展大众媒体宣传活动,以传播该问题的严重性,促使人们寻求医疗帮助,并促使健康专业人员进行诊断。

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