精神疾病中的脂质过氧化：临床证据概述
Lipid peroxidation in psychiatric illness: overview of clinical evidence.
作者信息
Joshi Yash B, Praticò Domenico
机构信息
Department of Pharmacology, Center for Translational Medicine, Temple University School of Medicine, MERB 947, 3500 North Broad Street, Philadelphia, PA 19140, USA.
出版信息
Oxid Med Cell Longev. 2014;2014:828702. doi: 10.1155/2014/828702. Epub 2014 Apr 27.
Abstract
The brain is known to be sensitive to oxidative stress and lipid peroxidation. While lipid peroxidation has been shown to contribute to many disease processes, its role in psychiatric illness has not been investigated until recently. In this paper, we provide an overview of lipid peroxidation in the central nervous system as well as clinical data supporting a link between lipid peroxidation and disorders such as schizophrenia, bipolar disorder, and major depressive disorder. These data support further investigation of lipid peroxidation in the effort to uncover therapeutic targets and biomarkers of psychiatric disease.
摘要
众所周知，大脑对氧化应激和脂质过氧化敏感。虽然脂质过氧化已被证明与许多疾病过程有关，但其在精神疾病中的作用直到最近才得到研究。在本文中，我们概述了中枢神经系统中的脂质过氧化以及支持脂质过氧化与精神分裂症、双相情感障碍和重度抑郁症等疾病之间存在联系的临床数据。这些数据支持进一步研究脂质过氧化，以努力发现精神疾病的治疗靶点和生物标志物。
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本文引用的文献
1
Oxidation and nitration in dopaminergic areas of the prefrontal cortex from patients with bipolar disorder and schizophrenia.
J Psychiatry Neurosci. 2014 Jul;39(4):276-85. doi: 10.1503/jpn.130155.
2
Alterations in circadian rhythms are associated with increased lipid peroxidation in females with bipolar disorder.
Int J Neuropsychopharmacol. 2014 May;17(5):715-22. doi: 10.1017/S1461145713001740. Epub 2014 Jan 17.
3
Oxidative stress in early stage Bipolar Disorder and the association with response to lithium.
J Psychiatr Res. 2014 Mar;50:36-41. doi: 10.1016/j.jpsychires.2013.11.011. Epub 2013 Dec 6.
4
Impaired synthesis and antioxidant defense of glutathione in the cerebellum of autistic subjects: alterations in the activities and protein expression of glutathione-related enzymes.
Free Radic Biol Med. 2013 Dec;65:488-496. doi: 10.1016/j.freeradbiomed.2013.07.021. Epub 2013 Jul 26.
5
Lipid peroxidation and depressed mood in community-dwelling older men and women.
PLoS One. 2013 Jun 11;8(6):e65406. doi: 10.1371/journal.pone.0065406. Print 2013.
6
Reduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorder.
J Affect Disord. 2013 Sep 25;150(3):829-33. doi: 10.1016/j.jad.2013.03.011. Epub 2013 May 24.
7
Specific subcellular changes in oxidative stress in prefrontal cortex from patients with bipolar disorder.
J Neurochem. 2013 Nov;127(4):552-61. doi: 10.1111/jnc.12316. Epub 2013 Jun 11.
8
Lipid peroxidation markers in adult attention deficit hyperactivity disorder: new findings for oxidative stress.
Psychiatry Res. 2013 Oct 30;209(3):638-42. doi: 10.1016/j.psychres.2013.02.025. Epub 2013 May 13.
9
Cognitive function, plasma MnSOD activity, and MnSOD Ala-9Val polymorphism in patients with schizophrenia and normal controls.
Schizophr Bull. 2014 May;40(3):592-601. doi: 10.1093/schbul/sbt045. Epub 2013 Apr 15.
10
The relevance of oxidative stress status in first episode and recurrent depression.
J Affect Disord. 2012 Dec 20;143(1-3):34-8. doi: 10.1016/j.jad.2012.05.022. Epub 2012 Jul 25.
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