Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.
Nature. 2014 Jun 5;510(7503):58-67. doi: 10.1038/nature13475.
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches and animal models have generated a large body of evidence demonstrating that sphingolipid metabolites, particularly ceramide and sphingosine-1-phosphate, are signalling molecules that regulate a diverse range of cellular processes that are important in immunity, inflammation and inflammatory disorders. Recent insights into the molecular mechanisms of action of sphingolipid metabolites and new perspectives on their roles in regulating chronic inflammation have been reported. The knowledge gained in this emerging field will aid in the development of new therapeutic options for inflammatory disorders.
鞘脂类是真核细胞膜的普遍组成部分。我们对鞘脂代谢的理解的进展、最先进的鞘脂组学方法和动物模型已经产生了大量证据，证明鞘脂代谢物，特别是神经酰胺和鞘氨醇-1-磷酸，是调节免疫、炎症和炎症性疾病中多种细胞过程的信号分子。最近报道了对鞘脂代谢物作用的分子机制的深入了解以及它们在调节慢性炎症中的作用的新观点。在这个新兴领域中获得的知识将有助于为炎症性疾病开发新的治疗选择。
