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外源性类固醇治疗的管理问题。

Management issues with exogenous steroid therapy.

作者信息

Patt Hiren, Bandgar Tushar, Lila Anurag, Shah Nalini

机构信息

Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

出版信息

Indian J Endocrinol Metab. 2013 Dec;17(Suppl 3):S612-7. doi: 10.4103/2230-8210.123548.

Abstract

Glucocorticoids (GCs) are extensively used for various inflammatory and autoimmune disorders, but long term use of these agents is not without complications. Almost every GC formulations (e.g. oral, topical, inhaled, etc.) can cause systemic side effects. It can range from minor side effects (e.g. weight gain) to life-threatening effects (e.g. adrenal suppression, sepsis, etc.), which may require immediate intervention. Therefore, the decision to institute steroid therapy always requires careful consideration of the relative risk and benefit in each patient. The objectives of this study are to discuss monitoring of patients on GCs and management of the complications of GCs.

摘要

糖皮质激素(GCs)被广泛用于治疗各种炎症和自身免疫性疾病,但长期使用这些药物并非没有并发症。几乎每种GC制剂(如口服、局部、吸入等)都可能引起全身性副作用。其范围可从小的副作用(如体重增加)到危及生命的影响(如肾上腺抑制、败血症等),这可能需要立即干预。因此,决定采用类固醇治疗总是需要仔细考虑每个患者的相对风险和益处。本研究的目的是讨论对使用GCs患者的监测以及GCs并发症的管理。

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