5至7岁儿童中25-羟基维生素D与夜间遗尿症之间的关系。

Relationships between 25-hydroxyvitamin D and nocturnal enuresis in five- to seven-year-old children.

作者信息

Li Luanluan, Zhou Huafei, Yang Xin, Zhao Li, Yu Xiaodan

机构信息

MOE-Shanghai Key Lab of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Taizhou Hospital at Luqiao, Zhejiang Province, China.

出版信息

PLoS One. 2014 Jun 9;9(6):e99316. doi: 10.1371/journal.pone.0099316. eCollection 2014.

DOI:10.1371/journal.pone.0099316

PMID:24911026

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4050058/

Abstract

BACKGROUND

Vitamin D has been recognized to contribute to various physiological processes. However, no study has investigated serum 25-hydroxyvitamin D [25(OH)D] concentrations in children with nocturnal enuresis (NE) in the English literature.

OBJECTIVE

In the present study, serum 25(OH)D concentrations were measured in five- to seven-year-old children with NE and compared with those in non-enuretic children to investigate whether there was any relationship between 25(OH)D and NE as the first time in the literature.

DESIGN

Two hundred forty-seven five- to seven-year-old children were recruited from Taizhou, Zhejiang Province, China. Serum 25(OH)D concentrations were measured, and the structured questionnaire was administered to the parents of all children. Low 25(OH)D was defined as serum 25(OH)D concentrations below 20 ng/ml.

RESULTS

The prevalence of NE was 7.3% in the group of children with 25(OH)D concentrations that exceeded 20 ng/ml; this prevalence was much lower than the 17.5% observed in the group of children with 25(OH)D concentrations below 20 ng/ml (p<0.05). After adjusting for potential confounders, serum 25(OH)D (≥20 ng/ml) was significantly associated with NE and represented a protective factor against NE (OR = 0.31, 95%CI = 0.092, 1.0, P<0.05). A nonlinear relationship between 25(OH)D and NE was observed. The prevalence of NE decreased with increasing 25(OH)D concentrations above 19 ng/ml. Additionally, children exhibiting higher frequencies of bedwetting had lower 25(OH)D concentrations [5-7 times/week: 18.3±4.8; 2-4 times/week: 20.9±4.1; 0-1 times/week: 23.6±6.4 (ng/ml), P<0.05)].

CONCLUSIONS

Low 25(OH)D was associated with an increased risk of NE in children aged five to seven years.

摘要

背景

维生素D已被认为有助于多种生理过程。然而，英文文献中尚无研究调查夜间遗尿症（NE）患儿的血清25-羟基维生素D[25(OH)D]浓度。

目的

在本研究中，测量了5至7岁NE患儿的血清25(OH)D浓度，并与非遗尿症患儿的血清25(OH)D浓度进行比较，以首次在文献中探讨25(OH)D与NE之间是否存在任何关系。

设计

从中国浙江省台州市招募了247名5至7岁的儿童。测量血清25(OH)D浓度，并向所有儿童的家长发放结构化问卷。低25(OH)D定义为血清25(OH)D浓度低于20 ng/ml。

结果

25(OH)D浓度超过20 ng/ml的儿童组中NE的患病率为7.3%；该患病率远低于25(OH)D浓度低于20 ng/ml的儿童组中观察到的17.5%（p<0.05）。在调整潜在混杂因素后，血清25(OH)D（≥20 ng/ml）与NE显著相关，是预防NE的保护因素（OR = 0.31，95%CI = 0.092，1.0，P<0.05）。观察到25(OH)D与NE之间存在非线性关系。当25(OH)D浓度高于19 ng/ml时，NE的患病率随其浓度升高而降低。此外，尿床频率较高的儿童25(OH)D浓度较低[每周5 - 7次：18.3±4.8；每周2 - 4次：20.9±4.1；每周0 - 1次：23.6±6.4（ng/ml），P<0.05]。