NF-κB 依赖性信号传导和 p38 MAPK 信号通路在细胞生长抑制剂给药期间造血调控中的作用。
Role of NF-κB-dependent signaling and p38 MAPK signaling pathway in the control of hemopoiesis during cytostatic administration.
作者信息
Dygai A M, Zhdanov V V, Zyuz'kov G N, Udut E V, Miroshnichenko L A, Simanina E V, Chaikovskii A V, Stavrova L A, Danilets M G
机构信息
Research Institute of Pharmacology, Siberian Division of the Russian Academy of Sciences, Tomsk, Russia,
出版信息
Bull Exp Biol Med. 2014 May;157(1):32-6. doi: 10.1007/s10517-014-2485-1. Epub 2014 Jun 11.
The study examines the role of signal pathways in triggering the compensatory reactions in the blood system in response to the cytostatic administration. In vitro experiments elucidated the involvement of protein kinase p38 in the synthesis of granulocytic CSF by cells of hemopoietic microenvironment. The important role of the transcriptional factor NF-κB and protein kinase p38 in limitation of the processes of maturation of the hemopoietic precursors was demonstrated.
该研究考察了信号通路在触发血液系统针对细胞抑制剂给药的代偿反应中的作用。体外实验阐明了蛋白激酶p38参与造血微环境细胞合成粒细胞集落刺激因子（granulocytic CSF）的过程。研究证实了转录因子NF-κB和蛋白激酶p38在限制造血前体细胞成熟过程中的重要作用。
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