Buxton Jessica L, Das Shikta, Rodriguez Alina, Kaakinen Marika, Couto Alves Alexessander, Sebert Sylvain, Millwood Iona Y, Laitinen Jaana, O'Reilly Paul F, Jarvelin Marjo-Riitta, Blakemore Alexandra I F
Section of Investigative Medicine, Department of Medicine, Imperial College London, London, United Kingdom.
Department of Epidemiology and Biostatistics, Medical Research Council (MRC) Public Health England (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdom.
PLoS One. 2014 Jun 11;9(6):e99133. doi: 10.1371/journal.pone.0099133. eCollection 2014.
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing.
关于白细胞端粒长度（LTL）与肥胖的研究结果相互矛盾，而且体重指数（BMI）与一生中端粒长度之间的关系仍不明确。因此，我们测试了在5598名参与者中测量的成人LTL与以下因素的关联：i）儿童期生长指标（BMI和肥胖反弹年龄（AR））；ii）从儿童期到成年期BMI的变化；iii）成人BMI、腰臀比（WHR）、身体脂肪指数（BAI）。女性在AR时的儿童期BMI与31岁时的LTL呈正相关（P = 0.041）。男性（分别为P = 0.025和P = 0.049）和女性（分别为P = 0.029和P = 0.008）的成人BMI和WHR，以及女性的BAI（P = 0.021）与31岁时的LTL呈负相关。幼儿期到成年期标准化BMI的增加与女性成人LTL缩短有关（P = 0.008）。我们表明，LTL与男性和女性的多种肥胖指标呈负相关。此外，女性从儿童期到成年期BMI的增加与31岁时较短的端粒有关，这可能表明生物衰老加速。
