基于人群的浸润性微乳头状乳腺癌与浸润性导管癌的预后因素比较。
Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast.
机构信息
Department of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA.
Department of Radiation Oncology, Houston Methodist Hospital, 6565 Fannin St. DB-077, Houston, TX 77030 USA.
出版信息
Br J Cancer. 2014 Jul 29;111(3):619-22. doi: 10.1038/bjc.2014.301. Epub 2014 Jun 12.
BACKGROUND
Invasive micropapillary carcinoma (IMPC) is a variant of breast carcinoma with a higher propensity for lymph node metastases compared with invasive ductal carcinoma (IDC).
METHODS
Retrospective analysis of 636 IMPC and 297 735 IDC cases in the Surveillance, Epidemiology and End RESULTS database comparing disease-specific survival (DSS) and overall survival (OS) between IMPC and IDC.
RESULTS
A higher percentage of IMPC cases (52.0%) had nodal metastases compared with IDC cases (34.6%). The 5-year DSS and OS for IMPC was 91.8% and 82.9%, respectively compared with 88.6% and 80.5% for IDC, respectively. For both IMPC and IDC, oestrogen-receptor positivity was associated with better survival, while having four or more positive lymph nodes or larger tumour size correlated with worse survival. Radiotherapy provided a survival benefit for both histological types.
CONCLUSIONS
Despite IMPC's higher propensity for lymph node metastasis, IMPC has DSS and OS that compare favourably with IDC.
背景
浸润性微乳头状癌（IMPC）是一种乳腺癌变体，与浸润性导管癌（IDC）相比，其淋巴结转移的倾向更高。
方法
对监测、流行病学和结果数据库中的 636 例 IMPC 和 297735 例 IDC 病例进行回顾性分析，比较 IMPC 和 IDC 之间的疾病特异性生存率（DSS）和总生存率（OS）。
结果
与 IDC 病例（34.6%）相比，更多的 IMPC 病例（52.0%）存在淋巴结转移。IMPC 的 5 年 DSS 和 OS 分别为 91.8%和 82.9%，而 IDC 分别为 88.6%和 80.5%。对于 IMPC 和 IDC，雌激素受体阳性与更好的生存相关，而有 4 个或更多阳性淋巴结或更大的肿瘤大小与更差的生存相关。放疗对两种组织学类型都提供了生存获益。
结论
尽管 IMPC 淋巴结转移的倾向更高，但 DSS 和 OS 与 IDC 相比表现良好。
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