诺桑松脂素A-D，从元宝草中分离得到的4种新的脱羰多环多异戊烯基酰基间苯三酚。

Norsampsones A-D, four new decarbonyl polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii.

作者信息

Tian Wen-Jing, Yu Yang, Yao Xiao-Jun, Chen Hai-Feng, Dai Yi, Zhang Xiao-Kun, Yao Xin-Sheng

机构信息

College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.

出版信息

Org Lett. 2014 Jul 3;16(13):3448-51. doi: 10.1021/ol501333k. Epub 2014 Jun 16.

DOI:10.1021/ol501333k

PMID:24932990

Abstract

Norsampsones A-D (1-4), four new decarbonyl polycyclic polyprenylated acylphloroglucinols, together with a new biogenetically related compound hypersampsone M (5), were isolated from the aerial parts of Hypericum sampsonii. Norsampsones A-D featured an unprecedented carbon skeleton with the loss of C-2 carbonyl in the phloroglucinol ring. All structures were determined by extensive NMR spectroscopic methods, ECD calculation, and single-crystal X-ray diffraction.

摘要

从元宝草的地上部分分离得到了降桑普森酮A-D（1-4），四种新的脱羰基多环多异戊烯基酰基间苯三酚，以及一种新的生源相关化合物高桑普森酮M（5）。降桑普森酮A-D具有前所未有的碳骨架，间苯三酚环中的C-2羰基缺失。所有结构均通过广泛的核磁共振光谱方法、电子圆二色计算和单晶X射线衍射确定。