Suh-Lailam Brenda B, Haglock-Adler Carrie J, Carlisle Heidi J, Ohman Trent, McMillin Gwendolyn A
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
ARUP Laboratories, Salt Lake City, UT 84108, USA.
J Anal Toxicol. 2014 Sep;38(7):416-20. doi: 10.1093/jat/bku059. Epub 2014 Jun 17.
Laboratory detection of nicotine exposure is important for establishing eligibility for organ transplant and elective surgery. Nicotine testing is also used to verify compliance with nicotine replacement therapies (NRT), smoking cessation programs and for life insurance purposes. Nicotine metabolites, such as cotinine and trans-3'-hydroxycotinine, are used as biomarkers of nicotine exposure. For some clinical applications, it is important to distinguish between active use of tobacco products versus NRT. Anabasine is a tobacco alkaloid that has been used as a biomarker of active tobacco use. However, the use of anabasine as an insecticide, and its presence in consumables other than nicotine products, suggests that anabasine may not be specific to tobacco use/exposure. Here, we determine the reference interval for anabasine in the urine of nonsmokers and compare it to the range of anabasine concentrations observed in the presence or absence of nicotine metabolites.
实验室检测尼古丁暴露对于确定器官移植和择期手术的资格很重要。尼古丁检测还用于验证是否遵守尼古丁替代疗法（NRT）、戒烟计划以及用于人寿保险目的。尼古丁代谢物，如可替宁和反式-3'-羟基可替宁，被用作尼古丁暴露的生物标志物。对于某些临床应用，区分烟草制品的主动使用与NRT很重要。新烟草碱是一种烟草生物碱，已被用作主动吸烟的生物标志物。然而，新烟草碱作为杀虫剂的使用及其在尼古丁产品以外的消费品中的存在表明，新烟草碱可能并非烟草使用/暴露所特有。在此，我们确定了非吸烟者尿液中新烟草碱的参考区间，并将其与在有或没有尼古丁代谢物情况下观察到的新烟草碱浓度范围进行比较。
