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囊性纤维化的隆德-麦凯分期系统:翻修手术的一个预后因素?

Lund-mackay staging system in cystic fibrosis: a prognostic factor for revision surgery?

作者信息

Carter John M, Johnson Bradley T, Patel Amit, Palacios Enrique, Rodriguez Kimsey H

机构信息

Department of Otolaryngology-Head and Neck Surgery, Tulane University School of Medicine, New Orleans, LA.

Mercy Clinic Ear, Nose, and Throat-Surgery Center, Springfield, MO.

出版信息

Ochsner J. 2014 Summer;14(2):184-7.

Abstract

BACKGROUND

Cystic fibrosis (CF) is an autosomal recessive genetic disease that affects approximately 30,000 people in the United States. Mucus in CF patients can be exceptionally viscous, leading to progressive cycles of inflammation and infection. The most widely accepted staging system used to score sinus computed tomography (CT) scans is the Lund-Mackay Score (LMS).

METHODS

To determine if a significant correlation exists between LMS and the need for revision sinus surgery in a patient population with CF, we performed a retrospective review of 32 patients with CF who were referred to the Tulane Otolaryngology Clinic from 2005 to 2011 and received a CT scan of the paranasal sinuses. CT scans were graded in a blinded manner by the institution's neuroradiologist using the LMS system.

RESULTS

We found no statistically significant difference in the raw or scaled LMSs between patients receiving revision surgery (n=9) and patients receiving a single surgery (n=23).

CONCLUSIONS

CT scans are vital for preoperative planning, but they are not a useful tool for risk stratification. More specifically, application of the LMS is not relevant in identifying which CF patients with chronic rhinosinusitis will be at risk for revision surgeries.

摘要

背景

囊性纤维化(CF)是一种常染色体隐性遗传病,在美国约有30000人受其影响。CF患者的黏液可能异常黏稠,导致炎症和感染的渐进循环。用于鼻窦计算机断层扫描(CT)评分的最广泛接受的分期系统是伦德 - 麦凯评分(LMS)。

方法

为了确定在CF患者群体中LMS与鼻窦翻修手术需求之间是否存在显著相关性,我们对2005年至2011年转诊至杜兰大学耳鼻喉科诊所并接受鼻窦CT扫描的32例CF患者进行了回顾性研究。该机构的神经放射科医生使用LMS系统对CT扫描进行盲法分级。

结果

我们发现接受翻修手术的患者(n = 9)和接受单次手术的患者(n = 23)之间,原始或经缩放的LMS没有统计学上的显著差异。

结论

CT扫描对术前规划至关重要,但它们不是风险分层的有用工具。更具体地说,LMS的应用在识别哪些慢性鼻窦炎CF患者有翻修手术风险方面并不相关。

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