[中老年人体测量学参数与动脉硬化生物标志物之间的相关性]

[Correlation between anthropometric parameters and arteriosclerosis biomarker in the middle-aged and the elderly].

作者信息

Liu Yan, Qi Li-tong, Ma Wei, Yang Ying, Meng Lei, Zhang Bao-wei, Huo Yong

机构信息

Emergency Department, Yuquan Hospital of Qinghua University, Beijing 100049, China.

Department of Cardiology, Peking University First Hospital, Beijing 100034, China.

出版信息

Beijing Da Xue Xue Bao Yi Xue Ban. 2014 Jun 18;46(3):455-9.

PMID:24943028

Abstract

OBJECTIVE

To investigate the correlation between anthropometric indices and arteriosclerosis detection indicators in the middle-aged and the elderly.

METHODS

A cross-sectional descriptive study was made of 1 626 individuals (diabetics patients 23.37%, hypertensive subjects 39.48% and healthy individuals 37.15%), aged 45 to 90 years [mean age: (61.60 ± 10.22) years)] in Shijingshan District, Beijing. Their measurements: body mass index (BMI), waist circumference (WC), and waist to height ratio (WHtR). Arterial stiffness was assessed according to brachial-ankle pulse wave velocity (baPWV), intima-media thickness (IMT), augmentation index (AI) and ankle-brachial index (ABI), which were measured by noninvasive detectors and equipment. The correlations between the various indicators were analyzed.

RESULTS

The percentages of the hypertensive and diabetic groups of central obesity (male WC>85 cm, female WC>80 cm or WHtR>0.5) and of general obesity (BMI>28 kg/m²) were significantly higher than those of the healthy group (P<0.01). The difference between the two disease groups was not significant (P>0.05). There was a moderate positive correlation between the measures of abdominal obesity (WHtR and WC) and the general obesity indicators (BMI) (r=0.710 and 0.716). In the healthy group, WC and WHtR showed positive correlation with baPWV, IMT and ABI, and negative correlation with AI75. BMI showed positive correlation with IMT and negative correlation with AI75, and no correlation with baPWV and ABI. There was negative correlation between BMI and baPWV in the diabetic group. In the hypertension group, we found negative correlation between BMI and baPWV, maximum IMT, AI75, and also between WC and AI75. The simple regression straight line of baPWV versus the anthropometric parameters showed that the regression equations were y=0.949+1.379 x (baPWV vs. WHtR, R² = 0.046, P<0.001) and y=1.133+0.006x (baPWV vs. WC, R² = 0.027, P<0.001), respectively. baPWV and BMI did not have a linear relationship (P=0.62).

CONCLUSION

WHtR and WC are superior to BMI indices in predicting arteriosclerosis. Anthropometric measurements for central obesity are good predictors of cardiovascular risk.

摘要

目的

探讨中老年人群人体测量指标与动脉硬化检测指标之间的相关性。

方法

对北京市石景山区1626名年龄在45至90岁[平均年龄：(61.60±10.22)岁]的个体进行横断面描述性研究。这些个体包括糖尿病患者（23.37%）、高血压患者（39.48%）和健康个体（37.15%）。测量指标包括体重指数（BMI）、腰围（WC）和腰高比（WHtR）。采用无创检测仪和设备测量肱踝脉搏波速度（baPWV）、内膜中层厚度（IMT）、增强指数（AI）和踝臂指数（ABI）来评估动脉僵硬度。分析各项指标之间的相关性。

结果

高血压组和糖尿病组中心性肥胖（男性WC>85 cm，女性WC>80 cm或WHtR>0.5）和一般肥胖（BMI>28 kg/m²）的比例显著高于健康组（P<0.01）。两组疾病组之间的差异不显著（P>0.05）。腹部肥胖指标（WHtR和WC）与一般肥胖指标（BMI）之间存在中度正相关（r=0.710和0.716）。在健康组中，WC和WHtR与baPWV、IMT和ABI呈正相关，与AI75呈负相关。BMI与IMT呈正相关，与AI75呈负相关，与baPWV和ABI无相关性。糖尿病组中BMI与baPWV呈负相关。在高血压组中，发现BMI与baPWV、最大IMT、AI75之间以及WC与AI75之间呈负相关。baPWV与人体测量参数的简单回归直线显示，回归方程分别为y=0.949+1.379x（baPWV与WHtR，R² = 0.046，P<0.001）和y=1.133+0.006x（baPWV与WC，R² = 0.027，P<0.001）。baPWV与BMI没有线性关系（P=0.62）。