[1973 - 2013年墨西哥细菌对抗生素的耐药性演变]
[Evolution of bacterial resistance to antibiotics in México, 1973-2013].
作者信息
Rodríguez-Noriega Eduardo, León-Garnica Gerardo, Petersen-Morfín Santiago, Pérez-Gómez Héctor Raúl, González-Díaz Esteban, Morfín-Otero Rayo
机构信息
Infectología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara.
出版信息
Biomedica. 2014 Apr;34 Suppl 1:181-90. doi: 10.1590/S0120-41572014000500021.
INTRODUCTION
Bacterial resistance to antibiotics is a worldwide public health concern. Research priorities for the study and control of this emerging problem include country-wide surveillance.
OBJECTIVE
To review and comment on the contributions by Mexican investigators towards a greater understanding of the mechanisms of bacterial antibiotic resistance.
MATERIALS AND METHODS
A comprehensive search of the medical literature on Medline/PubMed between 1973 and July 2013 was performed.
RESULTS
The contributions of Mexican investigators have included descriptions of resistance in enteric pathogens, such as Salmonella Typhi, publications on the production of extended spectrum beta-lactamases, metallo-beta-lactamases, and carbapenemases, resistance mechanisms of Pseudomonas aeruginosa , and the evolution of resistance in Gram-positive pathogens, including Streptococcus pneumoniae , Staphylococcus aureus , and Enterococcus spp.
CONCLUSION
The Mexican literature on mechanisms of bacterial resistance is relevant for the development of plans to control the antibiotic resistance crisis.
引言
细菌对抗生素的耐药性是一个全球性的公共卫生问题。研究和控制这一新兴问题的研究重点包括全国范围的监测。
目的
回顾并评论墨西哥研究人员对更深入了解细菌抗生素耐药机制所做的贡献。
材料与方法
对1973年至2013年7月期间Medline/PubMed上的医学文献进行全面检索。
结果
墨西哥研究人员的贡献包括对肠道病原体（如伤寒沙门氏菌）耐药性的描述、关于超广谱β-内酰胺酶、金属β-内酰胺酶和碳青霉烯酶产生的出版物、铜绿假单胞菌的耐药机制，以及革兰氏阳性病原体（包括肺炎链球菌、金黄色葡萄球菌和肠球菌属）耐药性的演变。
结论
墨西哥有关细菌耐药机制的文献对于制定控制抗生素耐药危机的计划具有重要意义。
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