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胎盘植入的产前超声诊断——对母婴结局的影响

Prenatal sonographic diagnosis of placenta accreta--impact on maternal and neonatal outcomes.

作者信息

Hall Tania, Wax Joseph R, Lucas F Lee, Cartin Angelina, Jones Michael, Pinette Michael G

机构信息

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME.

出版信息

J Clin Ultrasound. 2014 Oct;42(8):449-55. doi: 10.1002/jcu.22186. Epub 2014 Jun 27.

Abstract

PURPOSE

To compare maternal and neonatal outcomes of prenatally diagnosed versus undiagnosed cases of placenta accreta.

METHODS

This retrospective study included all pathology-proven placentas accreta/increta/percreta from a single tertiary center from January 1, 2005 to December 31, 2012. Outcomes were compared between prenatally diagnosed and undiagnosed cases.

RESULTS

Thirty-six cases of abnormal implantations were identified, of which 19 (53%) were prenatally diagnosed by ultrasound. Prenatal detection was more likely with a percreta (7/19 versus 2/17, p = .07), parity (18/19 versus 9/17, p = .01), prior cesarean (17/19 versus 4/17, p = .0001), shorter cesarean-conception interval (22.8 ± 21.4 versus 108 ± 7.6 months, p = .01), and spontaneous conception (19/19 versus 12/17, p = .03). Cases diagnosed prenatally more frequently received steroids for fetal maturity (13/20 versus 3/19, p = .003), delivered by cesarean (19/19 versus 11/17, p = .01) under general anesthesia (14/19 versus 4/17, p = .002) with a cell saver (5/19 versus 0/17, p = .06). There were no statistically significant differences by group in maternal blood loss, transfusion, intensive care admission or length of stay, operative injury, or severe composite morbidity (reoperation, coagulopathy, thromboembolism, wound infection, multiorgan failure, transfusion reaction, fistula, or chest compressions). There were no statistically significant differences in 5-minute Apgar <7, neonatal intensive care unit admission or length of stay, or severe composite morbidity.

CONCLUSION

Prenatally undiagnosed accretas are less complex than prenatally diagnosed cases, but associated with statistically similar outcomes, suggesting benefit to prenatal recognition.

摘要

目的

比较产前诊断与未诊断的胎盘植入病例的孕产妇和新生儿结局。

方法

这项回顾性研究纳入了2005年1月1日至2012年12月31日期间来自单一三级中心的所有经病理证实的胎盘植入/穿透性植入/穿透性胎盘植入病例。比较产前诊断和未诊断病例的结局。

结果

共识别出36例异常植入病例,其中19例(53%)通过超声产前诊断。穿透性胎盘植入(7/19对2/17,p = 0.07)、经产妇(18/19对9/17,p = 0.01)、既往剖宫产史(17/19对4/17,p = 0.0001)、剖宫产与受孕间隔较短(22.8±21.4对108±7.6个月,p = 0.01)以及自然受孕(19/19对12/17,p = 0.03)时,产前检测的可能性更高。产前诊断的病例更常接受类固醇以促进胎儿成熟(13/20对3/19,p = 0.003),在全身麻醉下剖宫产分娩(19/19对11/17,p = 0.01)(14/19对4/17,p = 0.002)并使用血液回收机(5/19对0/17,p = 0.06)。两组在孕产妇失血、输血、重症监护入院或住院时间、手术损伤或严重复合并发症(再次手术、凝血病、血栓栓塞、伤口感染、多器官功能衰竭、输血反应、瘘管或胸外按压)方面无统计学显著差异。在5分钟Apgar评分<7、新生儿重症监护病房入院或住院时间或严重复合并发症方面也无统计学显著差异。

结论

产前未诊断的胎盘植入病例比产前诊断的病例病情较轻,但结局在统计学上相似,提示产前诊断有益。

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