脑肽与术后胃麻痹的调节
Brain peptides and the modulation of postoperative gastric ileus.
作者信息
Stengel Andreas, Taché Yvette
机构信息
Charité Center for Internal Medicine and Dermatology, Division of General Internal and Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
CURE: Digestive Diseases Research Center, Center for Neurobiology of Stress and Women's Health, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, CA 90073, USA.
出版信息
Curr Opin Pharmacol. 2014 Dec;19:31-7. doi: 10.1016/j.coph.2014.06.006. Epub 2014 Jul 9.
Postoperative ileus (POI) develops after abdominal surgery irrespective of the site of surgery. When prolonged, POI can lead to longer hospitalization times and higher healthcare costs. Moreover, it is associated with complaints for the patient. In order to develop new strategies to treat this condition, a deeper understanding of the pathophysiology of the POI is necessary. This review will focus on brain peptides (ghrelin, nesfatin-1, somatostatin, corticotropin-releasing factor, thyrotropin-releasing hormone and calcitonin gene-related peptide) involved in the mediation of POI and the possible modulation of these pathways to shorten the time of POI. Lastly, the role of vagal signaling or chewing gum as potential treatment strategies of alleviating symptoms of POI is discussed.
术后肠梗阻（POI）在腹部手术后发生，与手术部位无关。如果持续时间较长，POI会导致住院时间延长和医疗费用增加。此外，它还会给患者带来不适。为了制定治疗这种疾病的新策略，有必要更深入地了解POI的病理生理学。本综述将聚焦于参与介导POI的脑肽（胃饥饿素、nesfatin-1、生长抑素、促肾上腺皮质激素释放因子、促甲状腺激素释放激素和降钙素基因相关肽）以及对这些途径的可能调节，以缩短POI的时间。最后，讨论了迷走神经信号传导或咀嚼口香糖作为缓解POI症状的潜在治疗策略的作用。
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