一名患有神经纤维瘤病的患者身上的两例上皮样恶性神经鞘瘤。细胞学、组织学及DNA流式细胞术

Two epithelioid malignant schwannomas in a patient with neurofibromatosis. Cytology, histology and DNA-flow-cytometry.

作者信息

Molenaar W M, Ladde B E, Schraffordt Koops H, Dam-Meiring A

机构信息

Dept. of Pathology, University of Groningen, The Netherlands.

出版信息

Pathol Res Pract. 1989 May;184(5):529-34. doi: 10.1016/S0344-0338(89)80147-5.

DOI:10.1016/S0344-0338(89)80147-5

PMID:2501772

Abstract

Cytological, histological and DNA-ploidy findings of 2 epithelioid malignant schwannomas arising in a patient with von Recklinghausen's neurofibromatosis are described. In both primary tumors, i.e. in the thigh and in the thoracic wall, origin from a neurofibromatous nerve could be established. Within 2 years after the manifestation of the first malignant tumor the patient died of widely metastasized disease. DNA-flow cytometry of several neurofibromas revealed diploid stemlines, but both malignant primary tumors and a lung metastasis appeared to be aneuploid. Presumably, the primary tumors also contained cell populations with a diploid stem line.

摘要

描述了1例患有冯·雷克林霍增氏神经纤维瘤病患者发生的2例上皮样恶性神经鞘瘤的细胞学、组织学及DNA倍体分析结果。在两个原发肿瘤中，即在大腿和胸壁处，证实肿瘤起源于一条神经纤维瘤性神经。在第一个恶性肿瘤出现后的2年内，患者死于广泛转移的疾病。对几个神经纤维瘤进行的DNA流式细胞术检测显示为二倍体干细胞系，但两个原发性恶性肿瘤及一处肺转移灶似乎均为非整倍体。推测原发性肿瘤中也含有具有二倍体干细胞系的细胞群。