Ebagosti A, Gueunoun M, Favre R, Baralla A, Farisse P, Pons G, Barragan P, Gerard R, Levy S
Service de cardiologie, Centre hospitalo-universitaire Nord, Marseille.
Arch Mal Coeur Vaiss. 1989 Jun;82(6):935-9.
Cardiac complications of mediastinal irradiation usually concern the pericardium, the ventricular myocardium and the coronary arteries. We report the case of a 42-year old woman who experienced a syncopal atrioventricular (AV) block 12 years after irradiation of a mediastinal Hodgkin's lymphoma. Electrophysiological recordings showed infranodal conduction disturbances. A review of the literature yielded only 12 cases of syncopal radiation-induced AV block. This case highlights the risk of syncopal AV blocks occurring a long time after mediastinal irradiation and leading to severe damage of the His bundle and its branches. The presence, as in our patient, of an associated right ventricular outflow tract stenosis confirms the importance and severity of radiation-induced cardiac lesions.
纵隔放疗的心脏并发症通常涉及心包、心室心肌和冠状动脉。我们报告一例42岁女性患者,她在纵隔霍奇金淋巴瘤放疗12年后出现晕厥性房室传导阻滞。电生理记录显示结下传导障碍。文献回顾仅发现12例晕厥性放疗诱发的房室传导阻滞病例。该病例突出了纵隔放疗后很长时间发生晕厥性房室传导阻滞并导致希氏束及其分支严重损害的风险。如我们的患者一样,存在相关的右心室流出道狭窄证实了放疗诱发心脏病变的重要性和严重性。