核酸感应及其他：高迁移率族蛋白 B1 的优缺点。

Nucleic acid sensing and beyond: virtues and vices of high-mobility group box 1.

机构信息

Department of Molecular Immunology, Institute of Industrial Science, Max Planck-The University of Tokyo Center for Integrative Inflammology, The University of Tokyo, Tokyo, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo, Japan.

出版信息

J Intern Med. 2014 Nov;276(5):444-53. doi: 10.1111/joim.12285.

DOI:10.1111/joim.12285

PMID:25041239

Abstract

High-mobility group box 1 (HMGB1) was first described as an architectural chromatin-binding protein. Today, a wealth of evidence indicates that this protein is very versatile and serves an amazing assortment of roles in the nucleus, cytoplasm and extracellular milieu. As a result, HMGB1 is fast becoming recognized as a key regulator of protective and pathological immune responses. Whilst acknowledging the many functions of HMGB1 and its family members, we focus this review on their role as broad effectors of immune responses mediated by nucleic acids. In addition, we touch upon the recent progress in determining the in vivo role of HMGB1 as revealed by the study of mice conditionally null for the Hmgb1 gene.

摘要

高迁移率族蛋白 B1（HMGB1）最初被描述为一种结构染色质结合蛋白。如今，大量证据表明，这种蛋白质非常多样化，在细胞核、细胞质和细胞外环境中发挥着惊人的多种作用。因此，HMGB1 正迅速成为保护性和病理性免疫反应的关键调节剂。在承认 HMGB1 及其家族成员的许多功能的同时，我们专注于它们作为核酸介导的免疫反应的广泛效应物的作用。此外，我们还介绍了通过研究条件性敲除 Hmgb1 基因的小鼠来确定 HMGB1 体内作用的最新进展。