高血糖危象糖尿病患者氧化应激与促炎细胞因子的关联
The association of oxidative stress and pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis.
作者信息
Li Juan, Huang Minglian, Shen Xingping
机构信息
Department of Emergency, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian, China.
Department of Endocrinology, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian, China.
出版信息
J Diabetes Complications. 2014 Sep-Oct;28(5):662-6. doi: 10.1016/j.jdiacomp.2014.06.008. Epub 2014 Jun 19.
AIMS
To investigate the relationship between oxidative stress and serum levels of pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis.
METHODS
Seventy-three patients presenting to hospital with diabetic ketoacidosis or non-ketotic hyperglycemia were studied. Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC), 8-iso-prostaglandin F2α (8-iso-prostaglandinF2α, 8-iso-PGF2α), tumor necrosis factor receptor-I (TNF-RI), interleukin -1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were measured in all patients. The patients were then given an intravenous infusion of insulin 0.1U • kg-1 • h-1, as well as fluids, symptomatic therapy and parenteral and intravenous nutrition.
RESULTS CONCLUSION
Patients with hyperglycemic crises have significantly increased oxidative stress and dysregulated serum pro-inflammatory cytokines that can be effectively treated by intensive insulin therapy.
目的
探讨高血糖危象糖尿病患者氧化应激与血清促炎细胞因子水平之间的关系。
方法
对73例因糖尿病酮症酸中毒或非酮症高血糖入院的患者进行研究。检测所有患者的超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量、总抗氧化能力（TAC）、8-异前列腺素F2α（8-iso-前列腺素F2α，8-iso-PGF2α）、肿瘤坏死因子受体-I（TNF-RI）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平。然后给予患者静脉输注胰岛素0.1U•kg-1•h-1，以及补液、对症治疗和肠外及肠内营养。
结果结论
高血糖危象患者氧化应激显著增加，血清促炎细胞因子失调，强化胰岛素治疗可有效治疗。
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