生殖内分泌学：性激素结合球蛋白变体的功能影响。
Reproductive endocrinology: functional effects of sex hormone-binding globulin variants.
机构信息
Laboratory of Molecular Endocrinology, Gerontology and Geriatrics, KU Leuven and University Hospitals Leuven, Herestraat 49 PO Box 902, 3000 Leuven, Belgium.
Clinical and Experimental Endocrinology, KU Leuven and University Hospitals Leuven, Herestraat 49 PO Box 902, 3000 Leuven, Belgium.
出版信息
Nat Rev Endocrinol. 2014 Sep;10(9):516-7. doi: 10.1038/nrendo.2014.120. Epub 2014 Jul 22.
A new study has found eight single nucleotide polymorphisms in sex hormone-binding globulin that functionally affect its affinity for androgens or estrogens and other biochemical properties. This finding adds to growing concern about the ‘one size fits all’ approach in formulas to calculate free or bioavailable concentrations of estradiol and testosterone.
一项新的研究发现了 8 个性激素结合球蛋白的单核苷酸多态性，这些多态性在功能上影响其对雄激素或雌激素的亲和力和其他生化特性。这一发现增加了人们对公式计算雌二醇和睾酮的游离或生物可利用浓度的“一刀切”方法的担忧。
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