Wells Elizabeth A, Donovan Dennis M, Daley Dennis C, Doyle Suzanne R, Brigham Greg, Garrett Sharon B, Ingalsbe Michelle H, Hatch-Maillette Mary A, Perl Harold I, Walker Robrina
School of Social Work, University of Washington, Seattle, WA, USA; Alcohol and Drug Abuse Institute, University of Washington, Seattle, WA, USA.
Alcohol and Drug Abuse Institute, University of Washington, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
J Subst Abuse Treat. 2014 Oct;47(4):265-74. doi: 10.1016/j.jsat.2014.06.003. Epub 2014 Jun 14.
This study examined whether level of exposure to Stimulant Abuser Groups to Engage in 12-Step (STAGE-12), a 12-Step facilitative therapy, is related to treatment outcome. Data were from a large National Drug Abuse Treatment Clinical Trials Network (CTN) study comparing STAGE-12 combined with treatment-as-usual (TAU) to TAU alone. These analyses include only those randomized to STAGE-12 (n=234). Assessments occurred at baseline and 30, 60, 90, and 180 days following randomization. High-exposure patients (n=158; attended at least 2 of 3 individual, and 3 of 5 group, sessions), compared to those with less exposure (n=76), demonstrated: (1) higher odds of self-reported abstinence from, and lower rates of, stimulant and non-stimulant drug use; (2) lower probabilities of stimulant-positive urines; (3) more days of attending and lower odds of not attending 12-Step meetings; (4) greater likelihood of reporting no drug problems; (5) more days of duties at meetings; and (6) more types of 12-Step activities. Many of these differences declined over time, but several were still significant by the last follow-up. Treatment and research implications are discussed.
本研究考察了参与12步促进疗法(STAGE-12)的兴奋剂滥用者群体的暴露水平是否与治疗结果相关。数据来自一项大型国家药物滥用治疗临床试验网络(CTN)研究,该研究将STAGE-12联合常规治疗(TAU)与单纯TAU进行比较。这些分析仅包括随机分配至STAGE-12的患者(n = 234)。评估在基线以及随机分组后的第30、60、90和180天进行。与暴露较少的患者(n = 76)相比,高暴露患者(n = 158;参加了3次个体治疗中的至少2次以及5次团体治疗中的3次)表现出:(1)自我报告的兴奋剂和非兴奋剂药物戒断几率更高,使用频率更低;(2)兴奋剂尿检呈阳性的概率更低;(3)参加12步会议的天数更多,不参加的几率更低;(4)报告无药物问题的可能性更大;(5)在会议上承担职责的天数更多;(6)12步活动的类型更多。其中许多差异随时间推移而减小,但到最后一次随访时仍有几项差异显著。本文讨论了治疗和研究意义。